7.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · fixative
Amylcinnamyl Alcohol
Also known as: 3-Phenyl-2-methylpropan-1-ol, Amylcinnamic alcohol
Molecular Formula
C14H20O
Molecular Weight
204.31 g/mol
Category
fragrance ingredient
Bottom Line: Amylcinnamyl alcohol is generally considered safe in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- not combined with known allergens
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other fragrance products
✕ Avoid If:
- you have a known allergy to fragrances
- you experience irritation after use
- you are using on children under 3
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H20O |
| Molecular Weight | 204.31 g/mol |
| Boiling Point | 141.0°C |
| Solubility | miscible (in ethanol) |
| Log P | 4.4 |
Common Use Cases
5 Categories
Cosmetic
Perfumes, lotions, shampoos. Generally safe in cosmetics, but may cause irritation in sensitive individuals.
Food
Flavoring agents, baked goods. Used as a flavoring agent; ensure compliance with food safety standards.
Pharmaceutical
Topical creams, ointments. May be included in formulations; monitor for allergic reactions.
Household
Air fresheners, cleaning products. Commonly used in household products; use in well-ventilated areas.
Supplement
Flavoring in dietary supplements. Generally safe, but check for individual sensitivities.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Amylcinnamyl Alcohol is generally well tolerated on skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Amylcinnamyl Alcohol may lead to gastrointestinal discomfort; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation; immediate rinsing is recommended.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse reactions.
- pregnant — Limited safety data; consult healthcare provider.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- breastfeeding — Generally low risk but should be used cautiously.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is warranted. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Amylcinnamyl alcohol is assessed for safety in cosmetics and food, with some concerns about skin sensitization.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | Not a skin irritant | SCCS Opinion (2015) |
| Sensitization | possible sensitizer | Human sensitization study | Moderate concern for sensitization | EFSA Opinion (2014) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Amylcinnamyl alcohol is assessed for safety in cosmetics and food, with some concerns about skin sensitization.
- Commonly used as a fragrance ingredient.
- Potential for skin sensitization in sensitive individuals.
- Regulatory bodies have reviewed its safety.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Amylcinnamyl Alcohol
Year: 2012
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
SCCS
Report: Opinion on Amylcinnamyl Alcohol
Year: 2015
Conclusion: Considered safe in cosmetics with appropriate use.
View Full Report →
EFSA
Report: Scientific Opinion on Amylcinnamyl Alcohol
Year: 2014
Conclusion: Acceptable daily intake established; safe for food use.
View Full Report →
Regulatory Status
Global
Amylcinnamyl alcohol is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin may experience irritation. Patch testing is recommended.
Yes, it is permitted as a flavoring agent in food, but should be used within established limits.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:13:11.831602Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.