56.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · flavoring agent · solvent · aromatic compound
BENZENEPROPANAL, .ALPHA.-METHYL-4-(1-METHYLETHYL)-
Category
fragrance
Bottom Line: Generally considered safe for use in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in well-formulated products
- Concentration is within recommended limits
- Not applied to broken skin
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in high concentrations
- Combining with other fragrances
✕ Avoid If:
- You are pregnant or nursing
- You have a known allergy to similar compounds
- Using on irritated or damaged skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in moderation to avoid skin irritation.
Food
Flavoring agents, food additives. Generally safe in low concentrations.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider for use.
Household
Cleaning products, air fresheners. Ensure proper ventilation when using.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to benzenepropanal is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of benzenepropanal may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: High
Eye contact with benzenepropanal can cause irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
Toxicology Data
3 Endpoints
Research indicates that benzenepropanal is generally safe for use in cosmetics and food, though caution is advised.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Human repeated insult patch test | No sensitization reactions | EFSA Opinion (2017) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates that benzenepropanal is generally safe for use in cosmetics and food, though caution is advised.
- Used widely in fragrance formulations.
- Potential for skin sensitization in some individuals.
- Regulatory assessments support its safe use in specified concentrations.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Considered safe for use in cosmetics with restrictions.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2017
Conclusion: Safe for use in food flavoring at specified limits.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted with some restrictions in cosmetics in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Limited use in cosmetics
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, those with sensitive skin should use caution.
It's advisable to consult a healthcare provider before use during pregnancy.
Potential side effects include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:08:03.114081Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.