8.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
Fragrance · Solvent · Fixative · Odor Masking Agent
Octahydro-Tetramethyl-1-Naphthalenol
Molecular Formula
C14H24O
Molecular Weight
208.34 g/mol
Category
Fragrance Ingredient
Bottom Line: Generally regarded as safe in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in well-formulated products
- Applied to intact skin
- Used in recommended concentrations
⚠ Use with Awareness If:
- You have sensitive skin
- You are pregnant or nursing
- You have allergies to fragrances
✕ Avoid If:
- You experience irritation or allergic reactions
- You have a known sensitivity to similar compounds
- Using in high concentrations without testing
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H24O |
| Molecular Weight | 208.34 g/mol |
| Log P | 3.4 |
Common Use Cases
3 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetics when used as directed.
Household
Air fresheners, cleaning products. Use in well-ventilated areas to minimize inhalation risks.
Food
Flavoring agents. Limited data; use cautiously in food applications.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Octahydro-Tetramethyl-1-Naphthalenol is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may lead to gastrointestinal discomfort; moderate caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but prolonged exposure may cause respiratory irritation.
ocular
ocular
Risk Level: Low
Eye contact may cause mild irritation; generally, it is not a significant risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemicals; avoid exposure.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk.
- elderly — Generally safe but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for various substances. |
| pregnant | Moderate | Pregnant individuals may have heightened sensitivity to certain chemicals. |
| infants_children | High | Children's developing systems may react differently to substances. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Elderly individuals may have varying sensitivities to substances. |
Toxicology Data
3 Endpoints
Octahydro-Tetramethyl-1-Naphthalenol is primarily used as a fragrance ingredient with limited safety data available.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral | Low acute toxicity | CIR Safety Assessment (2018) |
| Skin Irritation | Non-irritating | Rabbit - Dermal | Not a skin irritant | SCCS Opinion (2020) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization Test | No sensitization observed | CIR Safety Assessment (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Octahydro-Tetramethyl-1-Naphthalenol is primarily used as a fragrance ingredient with limited safety data available.
- Used in cosmetics and household products
- Limited food safety data
- Potential for skin irritation in sensitive individuals
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2018
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2020
Conclusion: Safety concerns noted for certain populations; further studies recommended.
View Full Report →
EFSA
Report: Scientific Opinion on Flavouring
Year: 2019
Conclusion: Insufficient data to conclude on safety for food use; further research needed.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted in cosmetics but restricted in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Use limited to certain concentrations in cosmetics
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO DATA
None
Frequently Asked Questions
Caution is advised for sensitive skin; patch testing is recommended before use.
Limited data exists on its safety in food; use cautiously and consult regulations.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:26:50.377614Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.