6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · emollient · stabilizer
Trimethylbenzenepropanol
Molecular Formula
C12H18O
Molecular Weight
178.27 g/mol
Category
chemical compound
Bottom Line: Trimethylbenzenepropanol is generally considered safe for use in cosmetics and household products, though caution is advised for sensitive skin.
Quick Answer
✔ Generally Safe If:
- Used in well-formulated products
- Concentration is within recommended limits
- Not applied to broken skin
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing this ingredient
- Pregnant or nursing
✕ Avoid If:
- You have known allergies to similar compounds
- Using on irritated or damaged skin
- Using in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H18O |
| Molecular Weight | 178.27 g/mol |
| Log P | 3.1 |
Common Use Cases
3 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetic formulations; patch test recommended.
Pharmaceutical
Topical creams, ointments. Use under medical guidance; monitor for skin reactions.
Household
Cleaning agents, air fresheners. Follow usage instructions; ensure good ventilation.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Trimethylbenzenepropanol is generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may lead to gastrointestinal irritation; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may cause mild respiratory irritation; use in well-ventilated areas.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation; avoid direct exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to developing systems and potential for adverse reactions.
- pregnant — Limited data on safety during pregnancy; caution is warranted.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may exist. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Trimethylbenzenepropanol has been evaluated for safety in cosmetics and household products, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2018) |
| Skin Irritation | Non-irritating | Rabbit - Draize test | Not a skin irritant | SCCS Opinion (2020) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Review (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Trimethylbenzenepropanol has been evaluated for safety in cosmetics and household products, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally recognized as safe in cosmetic formulations.
- Potential for skin irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Trimethylbenzenepropanol
Year: 2018
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Trimethylbenzenepropanol
Year: 2020
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
FDA
Report: Regulatory Status of Trimethylbenzenepropanol
Year: 2021
Conclusion: No restrictions on use in cosmetics and household products.
View Full Report →
Regulatory Status
Global
Trimethylbenzenepropanol is permitted for use in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, those with sensitive skin should patch test products containing it.
Consult with a healthcare provider before using products containing this ingredient during pregnancy.
It is often found in fragrances, lotions, and household cleaning products.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T08:15:40.836300Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.