6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · solvent · fixative
(4-Tert-Butylcyclohexyl) Acetate
Molecular Formula
C12H22O2
Molecular Weight
198.30 g/mol
Category
fragrance ingredient
Bottom Line: Generally regarded as safe when used in low concentrations, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in well-formulated cosmetic products
- concentrations are kept below recommended limits
- not applied to broken skin
- used in ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in high concentrations
- applying to children or infants
- mixing with other strong fragrances
✕ Avoid If:
- you are pregnant or breastfeeding
- you have a known allergy to similar compounds
- you experience irritation upon use
- using in products intended for ingestion
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H22O2 |
| Molecular Weight | 198.30 g/mol |
| Log P | 3.4 |
Common Use Cases
5 Categories
Cosmetic
Perfumes, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, food additives. Generally safe in food applications at regulated levels.
Pharmaceutical
Topical creams, ointments. Monitor for allergic reactions when used in formulations.
Household
Air fresheners, cleaning products. Ensure good ventilation when using household products.
Supplement
Dietary supplements. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to (4-Tert-Butylcyclohexyl) Acetate is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of (4-Tert-Butylcyclohexyl) Acetate may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Moderate
Eye contact with (4-Tert-Butylcyclohexyl) Acetate may cause moderate irritation.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to chemical exposure due to developing systems.
- pregnant — Increased sensitivity may affect fetal development.
✔ Well-Tolerated Groups
- general_adult — Typically have a higher tolerance for exposure.
- elderly — Generally well tolerated but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for exposure compared to sensitive populations. |
| pregnant | Moderate | Pregnant individuals may have increased sensitivity to certain chemicals. |
| infants_children | High | Children are more vulnerable to chemical exposure due to their developing systems. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Elderly individuals may have varying sensitivities; monitor for reactions. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Research indicates (4-Tert-Butylcyclohexyl) Acetate is generally safe in regulated uses, though sensitivities may occur.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2015) |
| Sensitization | No sensitization observed | Human clinical study | Low sensitization potential | SCCS Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates (4-Tert-Butylcyclohexyl) Acetate is generally safe in regulated uses, though sensitivities may occur.
- Used widely in cosmetics and food flavoring.
- Potential for skin irritation in sensitive individuals.
- Regulatory reviews support its safe use within limits.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Considered safe for use in cosmetics with appropriate restrictions.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2017
Conclusion: Acceptable daily intake established for food use.
View Full Report →
Regulatory Status
Global
Regulatory status is generally favorable across major jurisdictions with specific guidelines. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
Use in cosmetics must comply with SCCS guidelines.
United Kingdom
UK GovernmentPERMITTED
Must comply with UK cosmetic regulations.
Canada
Health CanadaPERMITTED
Must comply with Health Canada guidelines.
Frequently Asked Questions
It may cause irritation in some individuals; patch testing is recommended.
Yes, it is permitted in food flavoring under regulated conditions.
Discontinue use immediately and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:38:47.049845Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.