6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · intermediate · stabilizer
2-Cyclohexylidene-2-Phenylacetonitrile
Molecular Formula
C14H15N
Molecular Weight
197.27 g/mol
Category
chemical compound
Bottom Line: 2-Cyclohexylidene-2-Phenylacetonitrile is generally considered safe for use in cosmetics and household products, though caution is advised based on individual sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in well-formulated products
- Applied in recommended concentrations
- No known allergies to similar compounds
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar ingredients
- Pregnant or nursing
✕ Avoid If:
- You experience irritation or allergic reactions
- Using on broken or damaged skin
- You are under medical treatment for skin conditions
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H15N |
| Molecular Weight | 197.27 g/mol |
| Log P | 3.6 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, sunscreens, hair products. Use in moderation and patch test for sensitivity.
Pharmaceutical
Topical treatments, medicated creams. Consult a healthcare provider before use.
Household
Cleaning agents, air fresheners. Ensure proper ventilation when using.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 2-Cyclohexylidene-2-Phenylacetonitrile is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this compound may pose moderate risks, particularly in larger amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this substance can cause significant irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — Typically low to moderate risk with monitoring.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known severe reactions. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Moderate | Potential for transfer through breast milk; limited data available. |
| elderly | Low to Moderate | Elderly may have increased sensitivity to chemicals. |
Toxicology Data
3 Endpoints
Current assessments indicate moderate safety for 2-Cyclohexylidene-2-Phenylacetonitrile in cosmetics and household products.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | SCCS Opinion (2022) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization potential | FDA Regulatory Review (2023) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Current assessments indicate moderate safety for 2-Cyclohexylidene-2-Phenylacetonitrile in cosmetics and household products.
- Limited data on long-term exposure.
- Potential for skin irritation in sensitive individuals.
- Regulatory reviews ongoing in multiple jurisdictions.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 2-Cyclohexylidene-2-Phenylacetonitrile
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on 2-Cyclohexylidene-2-Phenylacetonitrile
Year: 2022
Conclusion: Safety concerns noted for sensitive skin types.
View Full Report →
FDA
Report: Regulatory Status of 2-Cyclohexylidene-2-Phenylacetonitrile
Year: 2023
Conclusion: No specific restrictions; safe for use in cosmetics.
View Full Report →
Regulatory Status
Global
2-Cyclohexylidene-2-Phenylacetonitrile is generally permitted in major markets with ongoing reviews in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionUNDER REVIEW
Pending further safety assessments
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should exercise caution and perform patch tests.
Consult with a healthcare provider before using products with this ingredient if pregnant or nursing.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:02:56.593473Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.