7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer · emollient
2-Ethyl-4-(2,2,3-Trimethylcyclopent-3-En-1-Yl)But-2-En-1-Ol
Molecular Formula
C14H24O
Molecular Weight
208.34 g/mol
Category
chemical compound
Bottom Line: Generally regarded as safe when used appropriately, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not combined with known irritants
- Conducted patch testing prior to widespread use
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in conjunction with other active ingredients
- Pregnant or nursing
✕ Avoid If:
- You have a known allergy to similar compounds
- Experiencing skin irritation or adverse reactions
- Using on broken or compromised skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H24O |
| Molecular Weight | 208.34 g/mol |
| Log P | 3.6 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair products. Use in moderation and perform patch tests.
Food
Flavoring agents, food additives. Generally safe in food applications at regulated levels.
Pharmaceutical
Topical medications, oral formulations. Consult healthcare providers for use in medications.
Supplement
Dietary supplements, herbal products. Use under guidance of a healthcare professional.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration and exposure duration.
ocular
ocular
Risk Level: High
Eye contact may cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to potential for increased sensitivity.
- pregnant — Caution advised due to limited safety data.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally low to moderate risk, but monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity in infants and children may lead to adverse effects. |
| breastfeeding | Insufficient Data | Safety during breastfeeding is not well established. |
| elderly | Low to Moderate | Elderly individuals may have increased sensitivity to ingredients. |
Toxicology Data
3 Endpoints
Limited data suggests moderate safety for topical and food use, though individual reactions may vary.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data for acute toxicity | — |
| Skin Irritation | Mildly irritating | Human patch test | Low concern for irritation | CIR Safety Assessment (2021) |
| Sensitization | Non-sensitizing | Human clinical trial | Low concern for sensitization | EFSA Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Limited data suggests moderate safety for topical and food use, though individual reactions may vary.
- Potential for skin irritation in sensitive individuals
- Regulatory assessments indicate moderate safety
- Further studies needed for comprehensive safety profile
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 2-Ethyl-4-(2,2,3-Trimethylcyclopent-3-En-1-Yl)But-2-En-1-Ol
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on the safety of 2-Ethyl-4-(2,2,3-Trimethylcyclopent-3-En-1-Yl)But-2-En-1-Ol
Year: 2020
Conclusion: Considered safe for use in food applications within established limits.
View Full Report →
FDA
Report: Regulatory Status of 2-Ethyl-4-(2,2,3-Trimethylcyclopent-3-En-1-Yl)But-2-En-1-Ol
Year: 2022
Conclusion: No restrictions on use in cosmetics and food products.
View Full Report →
Regulatory Status
Global
Generally permitted across major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe for skin use, though patch testing is advised for sensitive individuals.
Yes, it is permitted in food applications within established safety limits.
Some individuals may experience irritation; discontinue use if adverse reactions occur.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:05:14.896355Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.