8.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · fixative · antimicrobial agent · potential skin conditioning agent
Santalol
Also known as: alpha-santalol, beta-santalol
Molecular Formula
C15H24O
Molecular Weight
220.35 g/mol
Category
fragrance
Bottom Line: Santalol is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- not combined with known allergens
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or breastfeeding
- you are using other topical products
✕ Avoid If:
- you have a known allergy to sandalwood
- you experience irritation after use
- you are using it in high concentrations
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H24O |
| Molecular Weight | 220.35 g/mol |
| Solubility | Miscible at room temperature (in ethanol) |
| Log P | 4 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, soaps. Generally safe in cosmetics, but patch test recommended.
Food
Flavoring agents, beverages. Used in food flavoring; ensure compliance with local regulations.
Pharmaceutical
Topical ointments, medicated creams. Use with caution in sensitive individuals.
Supplement
Aromatherapy oils, dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Santalol is generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of santalol may cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse reactions.
- pregnant — Limited safety data; consult healthcare provider.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with low irritation potential.
- breastfeeding — Use with caution; monitor infants for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in young children; potential for adverse reactions. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Santalol is a fragrance compound with potential allergenic properties. Safety assessments indicate moderate risk for sensitive individuals.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2015) |
| Sensitization | moderate sensitizer | Human sensitization study | Potential for allergic reactions | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Santalol is a fragrance compound with potential allergenic properties. Safety assessments indicate moderate risk for sensitive individuals.
- Commonly used in cosmetics and food products.
- May cause allergic reactions in some users.
- Regulatory assessments vary by region.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Santalol
Year: 2012
Conclusion: Santalol is safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Santalol
Year: 2015
Conclusion: Santalol is safe for use in cosmetics with restrictions on concentration.
View Full Report →
EFSA
Report: Scientific Opinion on Santalol
Year: 2018
Conclusion: Santalol is acceptable for use in food flavoring under specified conditions.
View Full Report →
Regulatory Status
Global
Santalol is permitted in cosmetics and food, with some restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Max 1% in cosmetics
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Santalol is generally safe, but individuals with sensitive skin should patch test first.
Yes, Santalol may cause allergic reactions in some individuals, particularly those with sensitivities.
Santalol is permitted in food flavoring under specific conditions set by EFSA.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:54:57.756306Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.