10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · emollient
Methyl Nonylenate
Molecular Formula
C10H18O2
Molecular Weight
170.25 g/mol
Category
chemical compound
Bottom Line: Methyl Nonylenate is generally considered safe for use in cosmetics and pharmaceuticals, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken skin
- Used as directed in food supplements
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or breastfeeding
- You are using other active ingredients
✕ Avoid If:
- You have a known allergy to similar compounds
- You experience irritation or adverse reactions
- You are using it in high concentrations
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H18O2 |
| Molecular Weight | 170.25 g/mol |
| Solubility | Soluble (in ethanol) |
| Log P | 3.5 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, skin creams, lotions. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food supplements. Use within recommended limits; consult a healthcare provider.
Pharmaceutical
Topical medications, transdermal patches. Follow dosage instructions; monitor for skin reactions.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Methyl Nonylenate is generally well tolerated on the skin with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact can lead to significant irritation and discomfort, requiring immediate rinsing.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk of adverse effects.
- elderly — Generally well tolerated with minimal risk.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for Methyl Nonylenate exposure. |
| pregnant | Moderate | Limited data on the effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Elderly individuals generally tolerate Methyl Nonylenate well. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Methyl Nonylenate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Methyl Nonylenate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally recognized as safe in cosmetic formulations.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Methyl Nonylenate
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Methyl Nonylenate
Year: 2018
Conclusion: Considered safe for use in food flavoring.
View Full Report →
FDA
Report: Regulatory Status of Methyl Nonylenate
Year: 2020
Conclusion: Permitted in cosmetic and food products under specific guidelines.
View Full Report →
Regulatory Status
Global
Methyl Nonylenate is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test products containing it.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Potential side effects may include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:57:48.056162Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.