8.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · skin conditioning agent · antioxidant · UV filter
Methyl 2-[[3-(4-Methoxyphenyl)-2-Methylpropylidene]Amino]Benzoate
Molecular Formula
C19H21NO3
Molecular Weight
311.4 g/mol
Category
chemical compound
Bottom Line: Methyl 2-[[3-(4-Methoxyphenyl)-2-Methylpropylidene]Amino]Benzoate is generally considered safe in cosmetics and supplements, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Not applied to broken skin
- Used in well-formulated products
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using alongside other active ingredients
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to similar compounds
- Experiencing skin irritation or reactions
- Using on children without consulting a physician
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C19H21NO3 |
| Molecular Weight | 311.4 g/mol |
| Log P | 3.8 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, sunscreens, moisturizers. Generally safe for topical use in cosmetics.
Pharmaceutical
Topical analgesics, anti-inflammatory creams. Use under medical supervision for therapeutic applications.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Methyl 2-[[3-(4-Methoxyphenyl)-2-Methylpropylidene]Amino]Benzoate is generally considered low risk.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly in high doses or sensitive individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this substance may cause significant irritation or damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Children are at a higher risk due to increased sensitivity.
- sensitive_skin — Individuals with sensitive skin may react adversely.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated in adults.
- elderly — Typically low to moderate risk for elderly individuals.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Moderate | Limited data on excretion in breast milk; caution is warranted. |
| elderly | Low to Moderate | Elderly individuals may have varying sensitivities. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Methyl 2-[[3-(4-Methoxyphenyl)-2-Methylpropylidene]Amino]Benzoate has limited safety data, with some studies indicating low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data | CIR Safety Assessment (2021) |
| Skin Irritation | Mild irritant | Human patch test | Low concern for general use | SCCS Opinion (2022) |
| Sensitization | Non-sensitizing | Human clinical trial | Low risk of sensitization | FDA Regulatory Review (2023) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Methyl 2-[[3-(4-Methoxyphenyl)-2-Methylpropylidene]Amino]Benzoate has limited safety data, with some studies indicating low toxicity.
- Limited human data available
- Potential for skin irritation
- Regulatory assessments ongoing
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Methyl 2-[[3-(4-Methoxyphenyl)-2-Methylpropylidene]Amino]Benzoate
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Methyl 2-[[3-(4-Methoxyphenyl)-2-Methylpropylidene]Amino]Benzoate
Year: 2022
Conclusion: Requires further investigation for safety in cosmetic use.
View Full Report →
FDA
Report: Regulatory Status of Methyl 2-[[3-(4-Methoxyphenyl)-2-Methylpropylidene]Amino]Benzoate
Year: 2023
Conclusion: No specific restrictions; generally recognized as safe in cosmetics.
View Full Report →
Regulatory Status
Global
Methyl 2-[[3-(4-Methoxyphenyl)-2-Methylpropylidene]Amino]Benzoate is permitted in the US and UK, under review in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionUNDER REVIEW
Pending further studies
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO_DATA
No specific data available
Frequently Asked Questions
It may cause irritation in sensitive individuals; patch testing is recommended.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Possible side effects include skin irritation and allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:36:26.751892Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.