7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer · emollient
(12e)-1-Oxacyclohexadec-12-En-2-One
Molecular Formula
C15H26O2
Molecular Weight
238.37 g/mol
Category
chemical compound
Bottom Line: Generally regarded as safe for use in cosmetics and food, though individual reactions may vary based on sensitivity.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to intact skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or adverse reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H26O2 |
| Molecular Weight | 238.37 g/mol |
| Log P | 5.2 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, shampoos. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food preservatives. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical ointments, medicated creams. Use under medical supervision for therapeutic applications.
Supplement
Dietary supplements, herbal extracts. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to (12e)-1-Oxacyclohexadec-12-En-2-One is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of (12e)-1-Oxacyclohexadec-12-En-2-One may pose moderate risks based on limited studies.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with (12e)-1-Oxacyclohexadec-12-En-2-One may cause irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and potential for adverse effects.
- pregnant — Limited safety data; caution advised.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with minimal adverse effects.
- elderly — Typically well tolerated, but health factors should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant adverse effects reported. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual health factors should be considered. |
Toxicology Data
3 Endpoints
Research indicates (12e)-1-Oxacyclohexadec-12-En-2-One is generally safe for cosmetic and food use, though individual sensitivities may occur.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2022) |
| Sensitization | not sensitizing | Human repeated insult patch test | No sensitization observed | EFSA Opinion (2023) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates (12e)-1-Oxacyclohexadec-12-En-2-One is generally safe for cosmetic and food use, though individual sensitivities may occur.
- Limited data on long-term effects.
- Potential for skin irritation in sensitive individuals.
- Regulatory assessments vary by region.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of (12e)-1-Oxacyclohexadec-12-En-2-One
Year: 2021
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on (12e)-1-Oxacyclohexadec-12-En-2-One
Year: 2022
Conclusion: Considered safe for cosmetic use with restrictions.
View Full Report →
EFSA
Report: Scientific Opinion on the safety of (12e)-1-Oxacyclohexadec-12-En-2-One in food
Year: 2023
Conclusion: No safety concerns at typical use levels.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted in the US and UK, restricted in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Use limited to specific applications
UK
UK GovernmentPERMITTED
None
CA
Health CanadaNO_DATA
None
Frequently Asked Questions
Generally safe for cosmetic use, but patch testing is recommended for sensitive skin.
Use with caution; patch test first to check for any adverse reactions.
Permitted in the US and UK, but restricted in the EU to specific applications.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:27:36.668171Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.