9.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · emollient
8-Tricyclo[5.2.1.02,6]Dec-3-Enyl Butanoate
Molecular Formula
C14H20O2
Molecular Weight
220.31 g/mol
Category
chemical compound
Bottom Line: 8-Tricyclo[5.2.1.02,6]Dec-3-Enyl Butanoate is generally considered safe for use in cosmetics and food, though caution is advised in sensitive populations.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not applied to broken skin
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- you are pregnant or nursing
- you are using other topical medications
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or adverse reactions
- you are using on children without consulting a doctor
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H20O2 |
| Molecular Weight | 220.31 g/mol |
| Log P | 3.4 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, skin creams, lotions. Generally safe for topical use; monitor for irritation.
Food
Flavoring agents, food additives. Used in small amounts; ensure compliance with food safety standards.
Pharmaceutical
Topical ointments, transdermal patches. Consult a healthcare professional before use.
Supplement
Dietary supplements, herbal products. Use under guidance; potential interactions with medications.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 8-Tricyclo[5.2.1.02,6]Dec-3-Enyl Butanoate is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 8-Tricyclo[5.2.1.02,6]Dec-3-Enyl Butanoate poses moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with 8-Tricyclo[5.2.1.02,6]Dec-3-Enyl Butanoate is associated with high risk of irritation.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk due to developing systems and potential for adverse reactions.
- pregnant — Caution advised due to limited safety data during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may occur. |
Toxicology Data
3 Endpoints
Research indicates that 8-Tricyclo[5.2.1.02,6]Dec-3-Enyl Butanoate is generally safe for cosmetic and food applications, though data is limited.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | EFSA Opinion (2020) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates that 8-Tricyclo[5.2.1.02,6]Dec-3-Enyl Butanoate is generally safe for cosmetic and food applications, though data is limited.
- Limited long-term safety data available.
- Potential for skin irritation in sensitive individuals.
- Regulatory assessments suggest cautious use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 8-Tricyclo[5.2.1.02,6]Dec-3-Enyl Butanoate
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on 8-Tricyclo[5.2.1.02,6]Dec-3-Enyl Butanoate
Year: 2020
Conclusion: Considered safe for use as a food flavoring agent within specified limits.
View Full Report →
FDA
Report: Food Additive Status
Year: 2022
Conclusion: No objections to the use of 8-Tricyclo[5.2.1.02,6]Dec-3-Enyl Butanoate in food applications.
View Full Report →
Regulatory Status
Global
8-Tricyclo[5.2.1.02,6]Dec-3-Enyl Butanoate is permitted in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Yes, it is generally considered safe for use in cosmetics when used as directed.
Caution is advised; perform a patch test before full application.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:53:07.903584Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.