7.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
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Fragrance ingredient · Solvent · Flavoring agent
Linalyl Acetate
Also known as: Linalyl Acetate, Linalyl Ethanoate
Molecular Formula
C12H20O2
Molecular Weight
196.29 g/mol
Category
Fragrance
Bottom Line: Linalyl acetate is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- not ingested in large amounts
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you have allergies to similar compounds
✕ Avoid If:
- you are allergic to linalool or similar compounds
- you have a history of skin reactions to fragrances
- you are using products for infants or young children
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H20O2 |
| Molecular Weight | 196.29 g/mol |
| Melting Point | 25.0°C |
| Boiling Point | 220.0°C |
| Solubility | 1 ml in 5 ml 70% alcohol (in ethanol) |
| Density | 0.895 g/cm³ |
| Log P | 3.3 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetics, but patch test recommended.
Food
Flavoring agents, beverages. Used in food flavoring; ensure compliance with local regulations.
Pharmaceutical
Topical ointments, medicated creams. Use with caution in medicinal products; consult a healthcare provider.
Supplement
Herbal supplements, aromatherapy oils. Consult a healthcare professional before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Linalyl acetate is generally well tolerated on the skin but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of linalyl acetate may lead to gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and discomfort, requiring immediate rinsing.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse reactions.
- pregnant — Limited safety data; use with caution.
- sensitive_skin — Increased likelihood of skin irritation.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- breastfeeding — Generally low risk but should be used cautiously.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; use with caution. |
| infants_children | High | Higher sensitivity in young children may lead to adverse reactions. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use cautiously. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Linalyl acetate is a fragrance compound with moderate safety data, though some individuals may experience sensitivities.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | SCCS Opinion (2018) |
| Sensitization | may cause sensitization | Human sensitization study | Moderate concern for sensitization | EFSA Opinion (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Linalyl acetate is a fragrance compound with moderate safety data, though some individuals may experience sensitivities.
- Commonly used in cosmetics and food products.
- Potential allergen for sensitive individuals.
- Regulatory assessments indicate moderate safety.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Linalyl Acetate
Year: 2012
Conclusion: Linalyl acetate is safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Linalyl Acetate
Year: 2018
Conclusion: Linalyl acetate is safe for use in cosmetic products with restrictions.
View Full Report →
EFSA
Report: Scientific Opinion on Linalyl Acetate
Year: 2015
Conclusion: Linalyl acetate is safe for use as a food flavoring agent.
View Full Report →
Regulatory Status
Global
Linalyl acetate is generally permitted in cosmetics and food, with some restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Limited use in cosmetics
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Linalyl acetate is generally safe for skin use, but patch testing is recommended for sensitive individuals.
Yes, linalyl acetate may cause allergic reactions in some individuals, especially those sensitive to fragrances.
Yes, linalyl acetate is permitted as a flavoring agent in food products under certain regulations.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:29:56.516329Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.