6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · aroma compound · solvent · flavoring agent
2,3-Dihydro-2,2,6-Trimethylbenzaldehyde
Molecular Formula
C10H14O
Molecular Weight
150.22 g/mol
Category
fragrance
Bottom Line: Generally regarded as safe in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin
- You are pregnant or nursing
- You have allergies to fragrances
✕ Avoid If:
- You have a known allergy to this ingredient
- You experience irritation upon use
- You are using on children without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H14O |
| Molecular Weight | 150.22 g/mol |
| Melting Point | 25.0°C |
| Boiling Point | 70.0°C |
| Solubility | Miscible at room temperature (in ethanol) |
| Log P | 2.1 |
Common Use Cases
4 Categories
Cosmetic
Perfumes, lotions, soaps. Use in moderation to avoid skin irritation.
Food
Flavoring agents, beverages. Generally safe in food applications at low levels.
Pharmaceutical
Topical creams, ointments. Consult a healthcare provider for sensitive skin use.
Supplement
Dietary supplements. Use as directed and consult a physician if unsure.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 2,3-Dihydro-2,2,6-Trimethylbenzaldehyde is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of this compound may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with this substance can cause significant irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated by healthy adults.
- elderly — Generally well tolerated, but individual responses may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
4 Endpoints
2,3-Dihydro-2,2,6-Trimethylbenzaldehyde is generally safe in cosmetics and food, though caution is advised for sensitive individuals.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | >5000 mg/kg | Rat - Oral | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Non-irritating | Rabbit - Dermal | Not a skin irritant | CIR Safety Assessment (2015) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization Test | No sensitization observed | CIR Safety Assessment (2015) |
| Eye Irritation | Mild irritant | Rabbit - Ocular | Mild irritation potential | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
2,3-Dihydro-2,2,6-Trimethylbenzaldehyde is generally safe in cosmetics and food, though caution is advised for sensitive individuals.
- Used widely in fragrances and flavorings
- May cause allergic reactions in some
- Regulatory assessments support its safety in low concentrations
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Allergens
Year: 2019
Conclusion: Fragrance allergens should be labeled; otherwise, generally safe.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2020
Conclusion: Considered safe for use in food at specified levels.
View Full Report →
Regulatory Status
Global
Generally permitted in cosmetics and food across major jurisdictions with labeling requirements for allergens. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
Labeling required for allergens
United Kingdom
UK GovernmentPERMITTED
Labeling required for allergens
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
It may cause irritation in sensitive individuals; patch testing is recommended.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:47:01.239619Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.