6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
pH adjuster · preservative · fragrance ingredient · stabilizer
3-(3-Methylbutyl)Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid
Molecular Formula
C13H20O2
Molecular Weight
208.30 g/mol
Category
Organic Acid
Bottom Line: Generally regarded as safe when used appropriately, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- In formulations designed for sensitive skin
- Not combined with known irritants
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using other active ingredients in your routine
- Pregnant or breastfeeding
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on broken or irritated skin
- Undergoing dermatological treatments
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H20O2 |
| Molecular Weight | 208.30 g/mol |
| Log P | 3.1 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, serums, moisturizers. Use in moderation to avoid irritation.
Food
Flavoring agents, food additives. Generally safe in food applications at low concentrations.
Pharmaceutical
Topical treatments, oral medications. Monitor for allergic reactions in sensitive individuals.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to this substance is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on exposure levels.
ocular
ocular
Risk Level: Very Low
Eye contact is associated with very low risk based on available evidence.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data necessitates caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
- elderly — Generally well tolerated with monitoring.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but individual health factors vary. |
Toxicology Data
3 Endpoints
Research indicates moderate safety for topical and food use, though individual sensitivities may occur.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data for acute toxicity | — |
| Skin Irritation | Mildly irritating | Human patch test | Low concern for irritation | CIR Safety Assessment (2021) |
| Sensitization | Non-sensitizing | Human clinical study | No sensitization observed | EFSA Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates moderate safety for topical and food use, though individual sensitivities may occur.
- Generally safe in cosmetics and food applications
- Potential for skin irritation in sensitive individuals
- Regulatory assessments support cautious use
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 3-(3-Methylbutyl)Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on the safety of 3-(3-Methylbutyl)Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid
Year: 2020
Conclusion: Considered safe for use as a food additive within specified limits.
View Full Report →
FDA
Report: Regulatory Status of 3-(3-Methylbutyl)Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid
Year: 2022
Conclusion: No restrictions on use in food and cosmetics.
View Full Report →
Regulatory Status
Global
Generally permitted across major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should test for irritation.
Yes, it is permitted as a food additive within specified limits.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:19:59.918481Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.