7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · fixative · solvent
Vetiveryl Acetate
Also known as: Vetiver Acetate, Vetiverol Acetate
Molecular Formula
C17H26O2
Molecular Weight
262.4 g/mol
Category
fragrance
Bottom Line: Vetiveryl Acetate is generally considered safe for use in cosmetics and fragrances, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you have allergies to similar compounds
✕ Avoid If:
- you experience irritation or allergic reactions
- you have a history of skin sensitivities
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C17H26O2 |
| Molecular Weight | 262.4 g/mol |
| Solubility | Soluble (in ethanol) |
| Log P | 3.6 |
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetics, but patch test first.
Food
Flavoring agents. Use in food is limited; check for specific regulations.
Pharmaceutical
Topical creams. Consult a healthcare provider for medicinal use.
Household
Air fresheners, cleaning products. Use in well-ventilated areas to avoid irritation.
Supplement
Aromatic oils. Not typically used in dietary supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Vetiveryl Acetate is generally considered safe for most individuals.
oral
oral
Risk Level: Moderate
Ingestion of Vetiveryl Acetate may pose moderate risks and should be avoided.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact with Vetiveryl Acetate can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse reactions due to sensitivity.
- pregnant — Limited safety data; caution advised.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with minimal risks.
- breastfeeding — Use with caution; consult healthcare provider.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Vetiveryl Acetate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not irritating | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Vetiveryl Acetate has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Generally recognized as safe in cosmetics.
- Limited data for food use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Vetiveryl Acetate
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Vetiveryl Acetate
Year: 2018
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2017
Conclusion: Insufficient data to establish safe levels for food use.
View Full Report →
Regulatory Status
Global
Vetiveryl Acetate is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Its use in food is limited; consult regulations for specific applications.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T08:32:10.454012Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.