4.0
ISS Score
D — Higher caution — limited safety data
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
flavor enhancer · aroma compound · solvent · intermediate
2-Furyl Methyl Ketone
Molecular Formula
C6H6O2
Molecular Weight
110.11 g/mol
Category
flavoring agent
Bottom Line: 2-Furyl Methyl Ketone is generally considered safe for use in food and cosmetics, though caution is advised due to potential sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in food and cosmetics
- Not applied to broken skin
- Used by individuals without known allergies to similar compounds
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or breastfeeding
- You are using other products containing similar flavoring agents
✕ Avoid If:
- You have a known allergy to 2-Furyl Methyl Ketone
- You experience irritation or adverse reactions upon use
- You are using it in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C6H6O2 |
| Molecular Weight | 110.11 g/mol |
| Melting Point | 33.0°C |
| Boiling Point | 67.0°C |
| Solubility | Soluble (in ethanol) |
| Log P | 0.5 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, beverages. Generally safe when used as directed in food products.
Pharmaceutical
Medications with flavoring. Consult a healthcare provider for use in medications.
Supplement
Nutritional supplements. Use cautiously and consult a professional if unsure.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 2-Furyl Methyl Ketone is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 2-Furyl Methyl Ketone may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with 2-Furyl Methyl Ketone can cause significant irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — Typically well tolerated, but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known severe adverse effects. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
2-Furyl Methyl Ketone has been evaluated for safety in food and cosmetic applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | Not a skin irritant | EFSA Opinion (2018) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
2-Furyl Methyl Ketone has been evaluated for safety in food and cosmetic applications, showing low toxicity.
- Low acute toxicity observed in studies.
- Potential for skin irritation in sensitive individuals.
- Regulatory assessments support its safe use in specified concentrations.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 2-Furyl Methyl Ketone
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
EFSA
Report: Scientific Opinion on 2-Furyl Methyl Ketone
Year: 2018
Conclusion: Considered safe for use as a flavoring agent in food.
View Full Report →
FDA
Report: Food Additive Status
Year: 2020
Conclusion: Permitted for use in food under specific conditions.
View Full Report →
Regulatory Status
Global
2-Furyl Methyl Ketone is generally permitted for use in food and cosmetics across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Use in food and cosmetics under specified conditions.
European Union
European CommissionPERMITTED
Allowed in food flavoring at specified levels.
United Kingdom
UK GovernmentPERMITTED
Regulated under UK food and cosmetic laws.
Canada
Health CanadaPERMITTED
Allowed in food and cosmetics under specific guidelines.
Frequently Asked Questions
Yes, it is generally considered safe for use in food flavoring at regulated levels.
It may cause irritation in sensitive individuals, so patch testing is recommended.
Discontinue use immediately and consult a healthcare professional for advice.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:07:37.239022Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.