7.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · aroma compound · solvent · stabilizer
Methylenedioxyphenyl Methylpropanal
Molecular Formula
C11H12O3
Molecular Weight
192.21 g/mol
Category
fragrance
Bottom Line: Methylenedioxyphenyl Methylpropanal is generally considered safe in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- properly diluted in formulations
- not applied to broken skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other fragrances
✕ Avoid If:
- you have known allergies to similar compounds
- you experience irritation upon use
- you are using it in food products without proper guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C11H12O3 |
| Molecular Weight | 192.21 g/mol |
| Solubility | soluble (in ethanol) |
| Log P | 2.2 |
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents. Consult regulations for safe usage levels.
Pharmaceutical
Topical creams. Ensure proper formulation to avoid skin reactions.
Household
Air fresheners, cleaning products. Use in well-ventilated areas to reduce inhalation risk.
Supplement
Dietary supplements. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Methylenedioxyphenyl Methylpropanal is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of Methylenedioxyphenyl Methylpropanal poses moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with Methylenedioxyphenyl Methylpropanal can cause significant irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may apply. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Methylenedioxyphenyl Methylpropanal has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Draize test | No significant irritation observed | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Guinea pig - Maximization test | No sensitization observed | EFSA Opinion (2019) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Methylenedioxyphenyl Methylpropanal has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Potential skin irritant for sensitive individuals.
- Regulatory reviews indicate safe use in cosmetics.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Methylenedioxyphenyl Methylpropanal
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
SCCS
Report: Opinion on Methylenedioxyphenyl Methylpropanal
Year: 2018
Conclusion: Considered safe in cosmetic products with restrictions.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring substances
Year: 2019
Conclusion: Safe for use in food flavorings at specified levels.
View Full Report →
Regulatory Status
Global
Methylenedioxyphenyl Methylpropanal is permitted in the US and restricted in the EU and UK for cosmetic use. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionRESTRICTED
Limited to cosmetic use only
UK
UK GovernmentRESTRICTED
Limited to cosmetic use only
CA
Health CanadaNO_DATA
No specific regulations identified
Frequently Asked Questions
It may cause irritation for sensitive individuals; patch testing is recommended.
Yes, but only at regulated levels; consult food safety guidelines.
In the EU, it is restricted to cosmetic use with a maximum concentration of 0.5%.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:50:05.037535Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.