66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · preservative · emollient
BENZENEPROPANOL
Category
chemical compound
Bottom Line: Generally, benzenepropanol is considered safe for use in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Formulated in products designed for skin contact
- Not used by individuals with known sensitivities
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar compounds
- Pregnant or nursing
✕ Avoid If:
- You have a known allergy to benzenepropanol
- Using on broken or irritated skin
- Ingesting or using in food products without proper guidance
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Facial creams, shampoos, lotions. Use in moderation and check for skin reactions.
Pharmaceutical
Topical ointments, medicated creams. Consult a healthcare provider for medicinal use.
Household
Cleaning agents, air fresheners. Ensure proper ventilation when using household products.
Food
Flavoring agents, preservatives. Regulatory approval is essential for food applications.
Supplement
Dietary supplements. Consult with a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to benzenepropanol is generally low risk for most individuals.
oral
oral
Risk Level: Moderate
Ingestion of benzenepropanol may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: High
Eye contact with benzenepropanol can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally well tolerated, but individual monitoring is advised.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but monitor for sensitivity. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Benzenepropanol is evaluated for safety in cosmetics and household products, with varying regulatory opinions.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Moderate acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Status (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Benzenepropanol is evaluated for safety in cosmetics and household products, with varying regulatory opinions.
- Generally recognized as safe in cosmetics at low concentrations.
- Limited data on food safety; regulatory approval required.
- Potential skin irritant for sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Benzenepropanol
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Benzenepropanol
Year: 2018
Conclusion: Considered safe in cosmetic products with proper labeling.
View Full Report →
FDA
Report: Regulatory Status of Benzenepropanol
Year: 2020
Conclusion: Permitted in cosmetics; no specific food use approved.
View Full Report →
Regulatory Status
Global
Benzenepropanol is generally permitted in cosmetics and household products across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should test for reactions.
Its use in food is not widely approved; consult regulations before use.
Discontinue use immediately and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T18:10:38.574446Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.