66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · flavoring agent · solvent · intermediate
1-Penten-3-One, 1-(2,6,6-Trimethyl-1-Cyclohexen-1-Yl)-
Molecular Formula
C14H22O
Molecular Weight
206.32 g/mol
Category
chemical compound
Bottom Line: 1-Penten-3-One is generally considered safe for use in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- not applied to broken skin
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you have allergies to similar compounds
✕ Avoid If:
- you experience irritation or allergic reactions
- you are using on children without guidance
- you have a history of respiratory issues
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H22O |
| Molecular Weight | 206.32 g/mol |
| Boiling Point | 102.0°C |
| Log P | 3.4 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetics; perform patch tests.
Food
Flavoring agents, food additives. Used as a flavoring; ensure compliance with food safety standards.
Pharmaceutical
Topical medications, prescription creams. Consult a healthcare provider for use in pharmaceuticals.
Supplement
Dietary supplements, herbal products. Use under guidance; effects may vary.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 1-Penten-3-One is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 1-Penten-3-One may pose moderate risks based on limited data.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: High
Eye contact with 1-Penten-3-One may cause significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure.
- pregnant — Limited safety data during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known severe reactions. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
Toxicology Data
3 Endpoints
1-Penten-3-One has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | CIR Safety Assessment (2015) |
| Sensitization | not sensitizing | Human patch test | No sensitization reactions reported | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
1-Penten-3-One has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity observed in studies.
- Generally recognized as safe in food applications.
- Limited skin irritation reported in cosmetic use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 1-Penten-3-One
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
EFSA
Report: Scientific Opinion on 1-Penten-3-One
Year: 2017
Conclusion: Considered safe for use as a flavoring substance.
View Full Report →
FDA
Report: Food Additive Status
Year: 2020
Conclusion: Permitted for use in food products under specified conditions.
View Full Report →
Regulatory Status
Global
1-Penten-3-One is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
Use in food and cosmetics under specified conditions.
EU
European CommissionPERMITTED
Allowed in cosmetics and food flavoring.
UK
UK GovernmentPERMITTED
Regulated under UK food and cosmetic laws.
CA
Health CanadaPERMITTED
Allowed in cosmetics and food products.
Frequently Asked Questions
Yes, it is generally considered safe when used in low concentrations.
Though rare, some individuals may experience allergic reactions; patch testing is recommended.
It is permitted for use in cosmetics and food in the US, EU, UK, and Canada.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-29T06:53:38.641281Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.