9.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · flavoring agent
Nopyl Acetate
Molecular Formula
C13H20O2
Molecular Weight
208.30 g/mol
Category
fragrance
Bottom Line: Nopyl Acetate is generally considered safe for use in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you have allergies to similar compounds
✕ Avoid If:
- you have a known allergy to Nopyl Acetate
- you are using products with high concentrations
- you experience irritation upon use
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H20O2 |
| Molecular Weight | 208.30 g/mol |
| Log P | 2.6 |
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetics when used as directed.
Food
Flavoring agents, food additives. Use within established limits for food applications.
Pharmaceutical
Topical medications, ointments. Monitor for skin reactions when used in pharmaceuticals.
Household
Cleaning products, air fresheners. Use in well-ventilated areas to avoid inhalation risks.
Supplement
Dietary supplements. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Nopyl Acetate is generally well tolerated on skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Nopyl Acetate may lead to gastrointestinal discomfort; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may cause respiratory irritation; use in well-ventilated areas.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation; avoid direct exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemicals may lead to adverse effects.
- pregnant — Limited data on safety during pregnancy; caution is advised.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally well tolerated, but individual sensitivities may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for sensitivity. |
Toxicology Data
3 Endpoints
Nopyl Acetate is evaluated for safety in cosmetics and food, showing low toxicity and minimal irritation potential.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Draize test | No irritation observed | SCCS Opinion (2016) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2017) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Nopyl Acetate is evaluated for safety in cosmetics and food, showing low toxicity and minimal irritation potential.
- Low acute toxicity observed in studies.
- Minimal skin irritation reported.
- Regulatory bodies support its safe use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Nopyl Acetate
Year: 2015
Conclusion: Nopyl Acetate is safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Nopyl Acetate
Year: 2016
Conclusion: Considered safe for cosmetic use with no significant risk.
View Full Report →
EFSA
Report: Scientific Opinion on Nopyl Acetate
Year: 2017
Conclusion: Acceptable daily intake established for food use.
View Full Report →
Regulatory Status
Global
Nopyl Acetate is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Yes, it is permitted as a flavoring agent in food, but within established limits.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:22:53.806498Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.