7.0
ISS Score
D+ — Higher caution — limited data
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
sunscreen agent · opacifying agent
Zinc Oxide
Molecular Formula
ZnO
Category
UV Filter
Bottom Line: Zinc oxide is generally considered safe for topical use, though individual reactions may vary depending on formulation and concentration.
Quick Answer
✔ Generally Safe If:
- Used in appropriate concentrations
- Formulated for topical application
- Not used on broken skin
⚠ Use with Awareness If:
- You have sensitive skin
- You are using other active ingredients
- You experience irritation
✕ Avoid If:
- You are allergic to zinc compounds
- You have open wounds
- You experience adverse reactions
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | ZnO |
| Solubility | insoluble in water |
Common Use Cases
1 Categories
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Zinc oxide is generally well tolerated when applied to the skin. However, some individuals may experience irritation.
oral
oral
Risk Level: Insufficient Data
Oral ingestion of zinc oxide is not recommended, and data on its safety in this route is limited.
inhalation
inhalation
Risk Level: Insufficient Data
Inhalation of zinc oxide particles may pose respiratory risks, but specific data is lacking.
ocular
ocular
Risk Level: Insufficient Data
Limited data is available regarding ocular exposure to zinc oxide, and caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- Pregnant Individuals — Limited data is available regarding the safety of zinc oxide during pregnancy.
✔ Well-Tolerated Groups
- General Adult Population — Generally well tolerated in topical applications.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| General Adult Population | Low | Zinc oxide is generally safe for adults when used in topical formulations. |
| Pregnant Individuals | Insufficient Data | Limited data is available regarding the safety of zinc oxide during pregnancy. |
| Infants and Children | Low | Zinc oxide is commonly used in diaper rash creams and sunscreens for children. |
Toxicology Data
0 Endpoints
Zinc oxide is widely used in cosmetics and has a long history of safe use, though specific studies on its safety are limited.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Zinc oxide is widely used in cosmetics and has a long history of safe use, though specific studies on its safety are limited.
- Commonly used as a sunscreen agent
- Generally recognized as safe for topical use
- Limited data on oral and inhalation exposure
Switch to Detailed mode to view full scientific assessments and citation database.
Pending formal assessment
Report: No formal safety assessment identified
Year: 2026
Conclusion: This ingredient has not been formally assessed by major regulatory or scientific bodies based on available records.
Regulatory Status
Global
Regulatory restrictions apply in some jurisdictions. Max 25% as UV filter; nano form with specific conditions Switch to Detailed mode for full regulatory breakdown.
European Union
European CommissionPERMITTED AS UV FILTER - ANNEX VI ENTRY 30
Max 25% as UV filter; nano form with specific conditions
United States
FDAOTC DRUG - SUNSCREEN ACTIVE UP TO 25%
Sunscreen: up to 25%
Frequently Asked Questions
Zinc oxide is commonly used in sunscreens and topical ointments for its UV filtering properties and skin protection.
Zinc oxide is generally considered safe for sensitive skin, but individual reactions may vary.
Ingestion of zinc oxide is not recommended, and safety data for oral use is limited.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 2023-10-01 | — |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.