7.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
preservative · antioxidant · stabilizer
Exaltolide
Also known as: Cyclopentadecanolide, Ethylene Brassylate
Trade Names: Exaltolide · Ambrettolide · Cetalox
Odor: Sweet, musky, powdery, lactonic, slightly woody
Molecular Formula
C17H24O
Molecular Weight
244.37 g/mol
Category
preservation
Bottom Line: Generally considered safe for use in cosmetics and food, though individual reactions may vary based on sensitivity.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- patch tested for skin sensitivity
- used in well-ventilated areas
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in conjunction with other active ingredients
- applying to broken or irritated skin
- consuming in large quantities
✕ Avoid If:
- you are pregnant or nursing without consulting a doctor
- you have a known allergy to similar compounds
- you experience adverse reactions upon use
- using in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C17H24O |
| Molecular Weight | 244.37 g/mol |
| Melting Point | 77.2°C |
| Boiling Point | 304.5°C |
| Solubility | soluble (in ethanol) |
| Log P | 5 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, shampoos, lotions. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food preservatives. Use within recommended limits; consult guidelines.
Pharmaceutical
Topical ointments, oral medications. Consult a healthcare professional for use.
Supplement
Dietary supplements, herbal extracts. Consult a doctor before use, especially in high doses.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally well tolerated with minimal irritation reported.
oral
oral
Risk Level: Moderate
Oral ingestion may pose moderate risks, particularly at higher doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Ocular exposure can lead to significant irritation and potential damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — This group is particularly vulnerable to adverse effects.
- pregnant — Potential risks to fetal development necessitate caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally low risk but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults may tolerate exposure well. |
| pregnant | Moderate | Pregnant individuals should exercise caution due to potential effects on fetal development. |
| infants_children | Very High | Infants and children are more susceptible to adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is advised. |
| elderly | Low | Elderly individuals may have altered sensitivity to substances. |
Toxicology Data
3 Endpoints
Research indicates moderate safety for cosmetic and food applications, though individual reactions may vary.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | CIR Safety Assessment (2021) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates moderate safety for cosmetic and food applications, though individual reactions may vary.
- Generally safe in recommended concentrations.
- Potential for irritation in sensitive individuals.
- Limited data on long-term effects.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ingredient
Year: 2021
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Food Additives
Year: 2020
Conclusion: Acceptable daily intake established; safe for food use.
View Full Report →
FDA
Report: Food and Drug Administration Regulations
Year: 2022
Conclusion: Generally recognized as safe when used as directed.
View Full Report →
Regulatory Status
Global
Overall, the ingredient is permitted for use across major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Yes, it is permitted in food applications, but adhere to recommended limits.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:07:25.791080Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.