7.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · stabilizer · emollient
2,4-Dimethyl-2-(5,5,8,8-Tetramethyl-6,7-Dihydronaphthalen-2-Yl)-1,3-Dioxolane
Molecular Formula
C19H28O2
Molecular Weight
288.4 g/mol
Category
chemical compound
Bottom Line: Generally regarded as safe when used appropriately, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in accordance with product guidelines
- Not combined with known irritants
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- You are using other active ingredients
✕ Avoid If:
- You have a known allergy to similar compounds
- You experience irritation upon first use
- You are using it in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C19H28O2 |
| Molecular Weight | 288.4 g/mol |
| Log P | 5.1 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, sunscreens, hair products. Use in moderation and patch test before full application.
Pharmaceutical
Topical ointments, prescription creams. Consult a healthcare provider for safe use.
Supplement
Dietary supplements, nutraceuticals. Follow dosage recommendations to avoid adverse effects.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to this substance is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly if consumed in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on exposure levels.
ocular
ocular
Risk Level: Moderate
Eye contact may cause moderate irritation; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risks.
- elderly — Generally low to moderate risk, but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in children; potential for adverse effects. |
| breastfeeding | Moderate | Limited data on excretion in breast milk; caution is warranted. |
| elderly | Low to Moderate | Elderly may have varied responses; monitor closely. |
Toxicology Data
3 Endpoints
Limited data available on safety and efficacy; further research is needed.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not determined | — | Insufficient data for classification | — |
| Skin Irritation | Mildly irritating | Human patch test | Low concern for general use | CIR Safety Assessment (2021) |
| Sensitization | Non-sensitizing | Human clinical study | Low risk of sensitization | SCCS Opinion (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Limited data available on safety and efficacy; further research is needed.
- Potential for skin irritation in sensitive individuals
- Regulatory assessments are ongoing
- Usage guidelines vary by product type
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 2,4-Dimethyl-2-(5,5,8,8-Tetramethyl-6,7-Dihydronaphthalen-2-Yl)-1,3-Dioxolane
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on 2,4-Dimethyl-2-(5,5,8,8-Tetramethyl-6,7-Dihydronaphthalen-2-Yl)-1,3-Dioxolane
Year: 2022
Conclusion: Requires further evaluation for safety in cosmetic applications.
View Full Report →
FDA
Report: Regulatory Status of 2,4-Dimethyl-2-(5,5,8,8-Tetramethyl-6,7-Dihydronaphthalen-2-Yl)-1,3-Dioxolane
Year: 2023
Conclusion: No specific regulations; generally recognized as safe in cosmetics.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted in the US and UK, under review in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionUNDER REVIEW
Pending further assessment
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO DATA
Unknown
Frequently Asked Questions
While generally safe, individuals with sensitive skin should exercise caution.
Consult a healthcare provider before using any products during pregnancy.
Discontinue use immediately and consult a dermatologist if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:50:17.662355Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.