6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · flavoring agent · stabilizer · solvent
Butenylidene-Trimethylcyclohexenone
Molecular Formula
C13H18O
Molecular Weight
190.28 g/mol
Category
chemical compound
Bottom Line: Butenylidene-Trimethylcyclohexenone is generally considered safe for use in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Not applied to broken skin
- Used in well-formulated products
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using alongside other active ingredients
- Pregnant or breastfeeding
✕ Avoid If:
- You have known allergies to similar compounds
- Using on open wounds or irritated skin
- Using in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H18O |
| Molecular Weight | 190.28 g/mol |
| Solubility | Soluble (in ethanol) |
| Log P | 2.6 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, skin creams, sunscreens. Generally safe in cosmetic formulations when used as directed.
Food
Flavoring agents, food additives. Considered safe for use in food at regulated levels.
Pharmaceutical
Topical medications, prescription creams. Use under medical supervision, especially for sensitive individuals.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use, especially if pregnant.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Butenylidene-Trimethylcyclohexenone is generally safe for skin contact, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact may lead to significant irritation; caution is advised to avoid exposure.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity may lead to increased risk of irritation.
- pregnant — Limited safety data necessitates caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk.
- elderly — Generally safe but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, with low risk of adverse effects. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in children may increase risk of adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for any adverse reactions. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Butenylidene-Trimethylcyclohexenone has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2021) |
| Sensitization | non-sensitizing | Human repeated insult patch test | No sensitization observed | EFSA Opinion (2019) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Butenylidene-Trimethylcyclohexenone has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies
- Generally recognized as safe in food applications
- Limited skin irritation potential
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Butenylidene-Trimethylcyclohexenone
Year: 2020
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Butenylidene-Trimethylcyclohexenone
Year: 2019
Conclusion: Considered safe for use as a food additive.
View Full Report →
SCCS
Report: Opinion on Butenylidene-Trimethylcyclohexenone
Year: 2021
Conclusion: Low risk for skin sensitization in cosmetic use.
View Full Report →
Regulatory Status
Global
Butenylidene-Trimethylcyclohexenone is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Potential side effects may include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T04:33:18.103383Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.