7.0
ISS Score
B — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · flavoring agent · aroma compound
Isocyclocitral
Molecular Formula
C10H16O
Molecular Weight
152.23 g/mol
Category
fragrance
Bottom Line: Isocyclocitral is generally considered safe in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- properly formulated in products
- not applied to broken skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using multiple fragrance products
✕ Avoid If:
- you have known allergies to fragrances
- you experience irritation or allergic reactions
- you are using on children without testing
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H16O |
| Molecular Weight | 152.23 g/mol |
| Melting Point | -55.0°C |
| Boiling Point | 214.0°C |
| Solubility | 106 mg/L @ 20 °C (exp) |
| Log P | 1.9 |
Common Use Cases
4 Categories
Cosmetic
Perfumes, lotions, shampoos. Generally safe in cosmetics when used as directed.
Food
Flavoring agents, beverages. Use in food is regulated; ensure compliance with guidelines.
Pharmaceutical
Topical creams, ointments. Use in pharmaceuticals should follow safety guidelines.
Household
Cleaning products, air fresheners. Safe in household products when used appropriately.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Isocyclocitral is generally well tolerated on the skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion of isocyclocitral may cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse reactions.
- pregnant — Limited safety data; caution advised.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally safe but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse reactions. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for sensitivities. |
Toxicology Data
3 Endpoints
Isocyclocitral is a fragrance ingredient with a favorable safety profile in cosmetics and food applications.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not irritating | SCCS Opinion (2019) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Isocyclocitral is a fragrance ingredient with a favorable safety profile in cosmetics and food applications.
- Widely used in cosmetic formulations.
- Generally recognized as safe in food applications.
- Regulatory bodies have assessed its safety.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Isocyclocitral
Year: 2015
Conclusion: Isocyclocitral is safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Isocyclocitral
Year: 2019
Conclusion: Isocyclocitral is safe for use in cosmetic products.
View Full Report →
EFSA
Report: Scientific Opinion on Isocyclocitral
Year: 2020
Conclusion: Isocyclocitral is safe for use as a flavoring substance.
View Full Report →
Regulatory Status
Global
Isocyclocitral is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Isocyclocitral is primarily used as a fragrance in cosmetics and food products.
While generally safe, individuals with sensitive skin should perform a patch test before use.
Though rare, some individuals may experience allergic reactions; discontinue use if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:22:20.652525Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.