66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
flavoring agent · fragrance component · aromatic compound · potential therapeutic agent
(+)-(1S, 2S, 3S, 5R)-2,6,6-
Category
natural compound
Bottom Line: Generally considered safe for use in cosmetics and supplements, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- No known allergies to similar compounds
- Formulated for intended use
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using alongside other active ingredients
- Pregnant or nursing
✕ Avoid If:
- You have a known allergy to this ingredient
- Experiencing skin irritation or redness
- Using on broken or damaged skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, serums, moisturizers. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, nutritional supplements. Generally recognized as safe when used appropriately.
Supplement
Dietary supplements, herbal extracts. Consult a healthcare provider before use.
Pharmaceutical
Active pharmaceutical ingredients, therapeutic agents. Use under medical supervision; efficacy varies.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally safe with minimal irritation reported.
oral
oral
Risk Level: Moderate
Oral ingestion may cause gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may irritate sensitive airways.
ocular
ocular
Risk Level: High
Eye contact can cause significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse reactions due to sensitivity.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal side effects.
- elderly — Generally safe but may require caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant adverse effects. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity to ingredients; potential for adverse reactions. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but may have increased sensitivity. |
Toxicology Data
3 Endpoints
Research indicates this natural compound is generally safe for use in cosmetics and food products.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | EFSA Opinion (2020) |
| Sensitization | not sensitizing | Human repeated insult patch test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates this natural compound is generally safe for use in cosmetics and food products.
- Widely used in cosmetic formulations
- Generally recognized as safe in food applications
- Limited reports of adverse reactions
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Natural Compounds
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Food Additives
Year: 2020
Conclusion: Considered safe for use in food products.
View Full Report →
FDA
Report: Regulatory Status of Natural Compounds
Year: 2022
Conclusion: Generally recognized as safe for intended uses.
View Full Report →
Regulatory Status
Global
Overall, this ingredient is permitted for use in major markets with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test.
Consult a healthcare provider before using any new products during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T17:13:35.552354Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.