7.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · antimicrobial agent · skin conditioning agent
P-Menthan-7-Ol
Molecular Formula
C10H20O
Molecular Weight
156.26 g/mol
Category
chemical compound
Bottom Line: P-Menthan-7-Ol is generally considered safe for use in cosmetics and food, though individual sensitivities may occur.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to intact skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other topical medications
✕ Avoid If:
- you have a known allergy to menthol
- you experience irritation or discomfort
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H20O |
| Molecular Weight | 156.26 g/mol |
| Solubility | Soluble (in ethanol) |
| Log P | 3 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, shampoos, body lotions. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, beverages. Used in small amounts; check for allergies.
Pharmaceutical
Topical analgesics, cough syrups. Effective for pain relief; use as directed.
Supplement
Herbal extracts, essential oils. Consult healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
P-Menthan-7-Ol is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Moderate
Ingestion may cause mild gastrointestinal discomfort in some individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and discomfort.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse reactions due to sensitivity.
- pregnant — Limited safety data; consult healthcare provider.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with low risk.
- elderly — Generally well tolerated; monitor for sensitivity.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; however, individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to ingredients; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data; potential for transfer through breast milk. |
| elderly | Low | Generally well tolerated, but monitor for sensitivity. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
P-Menthan-7-Ol has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | CIR Safety Assessment (2012) |
| Sensitization | not sensitizing | Human clinical trial | No sensitization reactions | CIR Safety Assessment (2012) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
P-Menthan-7-Ol has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity observed in studies.
- Generally recognized as safe in food applications.
- Commonly used in topical products.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Menthol and Related Compounds
Year: 2012
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Menthol
Year: 2017
Conclusion: Considered safe for use as a food flavoring.
View Full Report →
FDA
Report: Food Ingredients and Colors
Year: 2020
Conclusion: Generally recognized as safe (GRAS) for food use.
View Full Report →
Regulatory Status
Global
P-Menthan-7-Ol is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test first.
Consult your healthcare provider before using products containing this ingredient during pregnancy.
It is known for its cooling effect and is often used in topical analgesics and cosmetics.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:48:43.634800Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.