7.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · emollient · stabilizer · surfactant
2-T-Butylcyclohexyloxybutanol
Molecular Formula
C14H28O2
Molecular Weight
228.37 g/mol
Category
chemical compound
Bottom Line: Generally, 2-T-Butylcyclohexyloxybutanol is considered safe for use in cosmetics and household products, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Applied to intact skin
- Not combined with known irritants
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar ingredients
- You are pregnant or nursing
- You experience any adverse reactions
✕ Avoid If:
- You have a known allergy to similar compounds
- You have open wounds or broken skin
- Using on children without prior testing
- You are using products with conflicting active ingredients
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C14H28O2 |
| Molecular Weight | 228.37 g/mol |
| Log P | 3.8 |
Common Use Cases
3 Categories
Cosmetic
Moisturizers, sunscreens, hair conditioners. Generally safe for topical use; patch test recommended.
Pharmaceutical
Topical creams, ointments. Use as directed; monitor for skin reactions.
Household
Cleaning agents, air fresheners. Ensure good ventilation during use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 2-T-Butylcyclohexyloxybutanol is generally considered low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 2-T-Butylcyclohexyloxybutanol may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Moderate
Eye contact with 2-T-Butylcyclohexyloxybutanol may cause moderate irritation.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures may lead to adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no specific health conditions. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
Toxicology Data
3 Endpoints
2-T-Butylcyclohexyloxybutanol has been evaluated for safety in cosmetics and household products, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Non-irritating | Rabbit - Dermal application | No irritation observed | SCCS Opinion (2016) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Regulatory Review (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
2-T-Butylcyclohexyloxybutanol has been evaluated for safety in cosmetics and household products, showing low toxicity.
- Low acute toxicity in animal studies.
- No significant skin irritation reported.
- Generally recognized as safe in recommended uses.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 2-T-Butylcyclohexyloxybutanol
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on 2-T-Butylcyclohexyloxybutanol
Year: 2016
Conclusion: Considered safe for cosmetic use under specified conditions.
View Full Report →
FDA
Report: Regulatory Status of 2-T-Butylcyclohexyloxybutanol
Year: 2020
Conclusion: Permitted for use in cosmetics and household products.
View Full Report →
Regulatory Status
Global
2-T-Butylcyclohexyloxybutanol is permitted for use in major markets with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Consult with a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:18:02.608340Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.