8.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance agent · odor masking agent · aromatic compound · sensory enhancer
5-Methyl-1-(2,2,3-Trimethylcyclopentenyl)-6-Oxabicyclooctane
Molecular Formula
C16H26O
Molecular Weight
234.38 g/mol
Category
fragrance compound
Bottom Line: Generally regarded as safe in cosmetics and food, though individual sensitivities may occur.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- properly formulated in products
- not applied to broken skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are allergic to similar compounds
✕ Avoid If:
- you experience irritation or allergic reactions
- you have a known allergy to fragrance compounds
- you are using products on children without testing
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C16H26O |
| Molecular Weight | 234.38 g/mol |
| Log P | 3.6 |
Common Use Cases
4 Categories
Cosmetic
Fragrance oils, lotions, shampoos. Generally safe in cosmetic formulations when used appropriately.
Food
Flavoring agents, beverages. Used as a flavoring agent; ensure compliance with food safety standards.
Pharmaceutical
Topical medications, oral formulations. Use in pharmaceuticals should follow strict safety guidelines.
Supplement
Dietary supplements. Consult with a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to this ingredient is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly in high doses or sensitive individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: High
Eye contact may result in irritation or damage, indicating a high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- pregnant — Caution is advised due to limited safety data.
- infants_children — Higher sensitivity may lead to adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risks.
- elderly — Generally safe but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to potential effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but monitor for any adverse effects. |
Toxicology Data
3 Endpoints
5-Methyl-1-(2,2,3-Trimethylcyclopentenyl)-6-Oxabicyclooctane is a fragrance compound with limited safety data.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Mild irritant | Human patch test | Low concern for irritation | CIR Safety Assessment (2020) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for sensitization | SCCS Opinion (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
5-Methyl-1-(2,2,3-Trimethylcyclopentenyl)-6-Oxabicyclooctane is a fragrance compound with limited safety data.
- Used in cosmetics and food products.
- Potential for skin irritation in sensitive individuals.
- Regulatory assessments are ongoing.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2020
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2021
Conclusion: Requires further evaluation for potential sensitization.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring Compounds
Year: 2019
Conclusion: Considered safe for use in food at specified limits.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted in cosmetics and food. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionUNDER REVIEW
Pending further assessment
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, some individuals may experience irritation or allergies.
Consult with a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:44:11.443407Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.