55.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · intermediate in chemical synthesis · potential antimicrobial agent
BENZENE, 1-METHOXY-4-(2-PROPENYL)-
Category
aromatic compound
Bottom Line: Generally, benzene, 1-methoxy-4-(2-propenyl)- is used in various products, though safety depends on concentration and exposure.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations
- Applied in well-ventilated areas
- Not used on broken skin
⚠ Use with Awareness If:
- You have sensitive skin
- Using multiple products containing it
- Pregnant or breastfeeding
✕ Avoid If:
- You have a history of skin allergies
- Using on children
- You are exposed to high heat
Chemical Properties
| Property | Value |
|---|
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions. Use in low concentrations to minimize irritation.
Pharmaceutical
Topical creams, ointments. Follow dosage instructions carefully.
Household
Cleaning agents, air fresheners. Ensure good ventilation during use.
Food
Flavoring agents. Regulated for safe consumption levels.
Supplement
Herbal extracts. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Moderate
Skin contact with benzene, 1-methoxy-4-(2-propenyl)- may cause irritation or sensitization.
oral
oral
Risk Level: High
Ingestion of this substance can lead to serious health effects, including toxicity.
inhalation
inhalation
Risk Level: Very High
Inhalation poses significant risks, including respiratory irritation and systemic toxicity.
ocular
ocular
Risk Level: Moderate
Eye contact may cause irritation and potential damage to the eye.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to toxic effects.
- pregnant — Potential risks to fetal health.
✔ Well-Tolerated Groups
- general_adult — Generally can tolerate limited exposure.
- elderly — May tolerate with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Moderate | Adults may have varying sensitivities to benzene derivatives. |
| pregnant | High | Potential risks to fetal development from exposure. |
| infants_children | Very High | Children are more vulnerable to toxic effects. |
| breastfeeding | Moderate | Potential for transfer through breast milk. |
| elderly | Moderate | Elderly may have decreased resilience to toxic substances. |
Toxicology Data
3 Endpoints
Benzene, 1-methoxy-4-(2-propenyl)- has various uses but safety depends on exposure levels.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Non-irritating | Human patch test | Not a skin irritant | SCCS Opinion (2018) |
| Sensitization | No sensitization observed | Human repeated insult patch test | Low sensitization potential | FDA Regulatory Status (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Benzene, 1-methoxy-4-(2-propenyl)- has various uses but safety depends on exposure levels.
- Used in cosmetics and household products
- Safety varies by concentration
- Potential skin irritant
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Benzene, 1-Methoxy-4-(2-Propenyl)-
Year: 2015
Conclusion: Generally safe in cosmetics at low concentrations.
View Full Report →
SCCS
Report: Opinion on Benzene, 1-Methoxy-4-(2-Propenyl)-
Year: 2018
Conclusion: Safety concerns at high concentrations; further studies recommended.
View Full Report →
FDA
Report: Regulatory Status of Benzene, 1-Methoxy-4-(2-Propenyl)-
Year: 2020
Conclusion: Permitted in cosmetics with concentration limits.
View Full Report →
Regulatory Status
Global
Benzene, 1-methoxy-4-(2-propenyl)- is permitted in cosmetics with restrictions in major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
Limited to specific concentrations
European Union
European CommissionRESTRICTED
Must comply with SCCS recommendations
United Kingdom
UK GovernmentRESTRICTED
Follow EU guidelines post-Brexit
Canada
Health CanadaPERMITTED
Must meet safety standards
Frequently Asked Questions
Safety can vary; individuals with sensitive skin should use caution.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Yes, it is regulated for safe consumption levels; always check local guidelines.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T17:55:38.625122Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.