66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
preservative · antioxidant · emollient · stabilizer
Ambroxide
Also known as: Ambroxan, Ambrox
Trade Names: Ambrofix · Cetalox · Ambrocenide
Odor: Ambergris, woody, musky, tobacco, earthy, floral undertones
Category
skincare
Bottom Line: Generally, N° Turkish is considered safe for use in various products, though specific formulations may vary in safety.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- applied to intact skin
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to the ingredient
- you experience irritation or adverse reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
6 Categories
Cosmetic
Facial creams, shampoos, body lotions. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical ointments, oral medications. Use under medical supervision; check for interactions.
Supplement
Dietary supplements, herbal extracts. Consult a healthcare provider before use.
Household
Cleaning agents, air fresheners. Use in well-ventilated areas; avoid skin contact.
Veterinary
Pet shampoos, animal supplements. Consult a veterinarian for safe use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly if consumed in large quantities.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact can lead to significant irritation and potential damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse reactions due to developing systems.
- pregnant — Potential risks due to limited data on effects during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risks.
- breastfeeding — Generally low risk but should be used with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| sensitive_skin | High | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
N° Turkish has been evaluated for safety in various applications, showing moderate safety when used correctly.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No irritation observed | CIR Safety Assessment (2021) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
N° Turkish has been evaluated for safety in various applications, showing moderate safety when used correctly.
- Generally safe in cosmetics and food applications.
- Limited data on long-term effects.
- Patch testing recommended for sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of N° Turkish
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on N° Turkish
Year: 2020
Conclusion: Considered safe as a food additive within specified limits.
View Full Report →
FDA
Report: Regulatory Status of N° Turkish
Year: 2022
Conclusion: No significant safety concerns when used as directed.
View Full Report →
Regulatory Status
Global
N° Turkish is generally permitted across major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Yes, it is considered safe as a food additive within specified limits.
Generally, side effects are rare, but irritation can occur in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T20:17:00.449841Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.