66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
emollient · skin conditioning agent · fragrance ingredient · solvent
HEPTANOIC ACID, 2-PROPENYL ESTER
Category
fatty acid ester
Bottom Line: Heptanoic acid, 2-propenyl ester is generally considered safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not combined with known irritants
- Used in well-formulated products
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- You are using other active ingredients
✕ Avoid If:
- You have a known allergy to fatty acids
- You experience irritation upon use
- You are using it in high concentrations
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Considered safe for consumption in regulated amounts.
Pharmaceutical
Topical ointments, transdermal patches. Use in accordance with medical guidelines.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to heptanoic acid, 2-propenyl ester is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of heptanoic acid, 2-propenyl ester may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with heptanoic acid, 2-propenyl ester can cause irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited data; caution advised during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may apply. |
Toxicology Data
3 Endpoints
Heptanoic acid, 2-propenyl ester is evaluated for safety in cosmetics and food, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | CIR Safety Assessment (2015) |
| Sensitization | non-sensitizing | Human patch test | No sensitization observed | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Heptanoic acid, 2-propenyl ester is evaluated for safety in cosmetics and food, showing low toxicity.
- Low acute toxicity observed in studies
- Generally recognized as safe in food applications
- Limited irritation potential in cosmetic use
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Heptanoic Acid Esters
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Heptanoic Acid
Year: 2018
Conclusion: Considered safe for use as a food additive.
View Full Report →
FDA
Report: Food Additive Status
Year: 2020
Conclusion: Permitted for use in food applications.
View Full Report →
Regulatory Status
Global
Heptanoic acid, 2-propenyl ester is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe for skin use, but patch testing is recommended for sensitive individuals.
Yes, it is considered safe for consumption in regulated amounts as a food additive.
Side effects are rare, but some individuals may experience irritation or allergic reactions.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T19:07:19.621085Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.