9.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · aromatic compound · solvent · stabilizer
1-(2,6,10-Trimethylcyclododeca-2,5,9-Trien-1-Yl)Ethanone
Category
fragrance
Bottom Line: Generally regarded as safe for use in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in well-formulated products
- applied in recommended concentrations
- not combined with known irritants
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in high concentrations
- applying near eyes or mucous membranes
✕ Avoid If:
- you are pregnant or nursing
- you have a known allergy to similar compounds
- you experience irritation upon use
Chemical Properties
| Property | Value |
|---|
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in cosmetic formulations when used as directed.
Food
Flavoring agents. Limited data; use with caution in food applications.
Pharmaceutical
Topical medications. Use in pharmaceuticals is not well established; caution advised.
Household
Air fresheners, cleaning products. Safe in household products when used as intended.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to this substance is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly in high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on exposure levels.
ocular
ocular
Risk Level: High
Eye contact may cause significant irritation or damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Potential risks to fetal development.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
- elderly — Generally low to moderate risk, but monitor closely.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally healthy adults may tolerate this substance well. |
| pregnant | Moderate | Pregnant individuals should exercise caution due to potential risks. |
| infants_children | Very High | Infants and children are more sensitive to chemical exposures. |
| breastfeeding | Moderate | Limited data on effects during breastfeeding. |
| elderly | Low to Moderate | Elderly individuals may have varying sensitivities. |
Toxicology Data
3 Endpoints
Limited safety data available; generally safe in cosmetics but requires caution in food and pharmaceuticals.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2021) |
| Sensitization | Not sensitizing | Human patch test | Low sensitization potential | SCCS Opinion (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Limited safety data available; generally safe in cosmetics but requires caution in food and pharmaceuticals.
- Used primarily in fragrances and cosmetics.
- Safety assessments indicate moderate concern for sensitive individuals.
- Regulatory status varies across jurisdictions.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2021
Conclusion: Generally safe in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2020
Conclusion: Requires further investigation for food use; safe in cosmetics.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring Substances
Year: 2019
Conclusion: Insufficient data for safety in food applications.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted in cosmetics but restricted in food applications. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Limited use in food applications
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO_DATA
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should test for irritation.
Use in food is limited; caution is advised due to insufficient data.
Potential side effects include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:24:53.144364Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.