9.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
preservative · antioxidant · emulsifier
Ambropharm
Also known as: 1,5,6,7,8,8-Hexamethylindan-5-one, 2,6,7,8,8-pentamethyl-5-indanone
Trade Names: Ambropharm
Odor: Amber, woody, musky, powdery
Category
preservation
Bottom Line: Generally, this ingredient is considered safe for use in various products, though individual reactions may vary based on skin type and concentration.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not applied to broken skin
- Used in well-formulated products
⚠ Use with Awareness If:
- You have sensitive skin
- You are pregnant or nursing
- You are using other active ingredients
✕ Avoid If:
- You have a known allergy to this ingredient
- You experience irritation or adverse reactions
- You are using it in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|
Common Use Cases
6 Categories
Cosmetic
Facial creams, sunscreens, shampoos. Generally safe in cosmetic formulations when used as directed.
Food
Flavoring agents, food preservatives. Considered safe for consumption in regulated amounts.
Pharmaceutical
Topical medications, oral supplements. Use under medical supervision for therapeutic applications.
Supplement
Dietary supplements, herbal extracts. Consult a healthcare provider before use.
Household
Cleaning agents, air fresheners. Follow usage instructions to minimize risks.
Veterinary
Pet shampoos, animal supplements. Ensure products are specifically formulated for animals.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally safe with minimal irritation reported.
oral
oral
Risk Level: Moderate
Oral ingestion may pose moderate risks; caution is advised.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low but can vary based on concentration.
ocular
ocular
Risk Level: Very Low
Ocular exposure is generally very low risk with minor irritation possible.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to adverse effects.
- pregnant — Potential for increased sensitivity.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- breastfeeding — Typically safe with caution.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for exposure. |
| pregnant | Moderate | Pregnant individuals may have heightened sensitivity. |
| infants_children | High | Children are more vulnerable to potential toxicity. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk. |
Toxicology Data
3 Endpoints
This ingredient has been evaluated for safety in various applications, showing low toxicity and minimal irritation potential.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | CIR Safety Assessment (2021) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization potential | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
This ingredient has been evaluated for safety in various applications, showing low toxicity and minimal irritation potential.
- Low acute toxicity in animal studies.
- Minimal skin irritation reported.
- Generally recognized as safe in food applications.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ingredient
Year: 2021
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Food Safety
Year: 2020
Conclusion: Considered safe for use in food products within established limits.
View Full Report →
FDA
Report: Regulatory Status of Ingredient
Year: 2022
Conclusion: Permitted for use in food and cosmetics under specific guidelines.
View Full Report →
Regulatory Status
Global
This ingredient is generally permitted for use across major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:31:11.952559Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.