8.0
ISS Score
A- — Good — low to minimal hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · intermediate in organic synthesis · potential bioactive compound
Cyclopentadec-4-En-1-One
Molecular Formula
C15H26O
Molecular Weight
222.37 g/mol
Category
chemical compound
Bottom Line: Cyclopentadec-4-En-1-One is generally considered safe for use in cosmetics and pharmaceuticals, though caution is advised for sensitive skin.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- formulated in products for non-sensitive skin
- properly tested for skin compatibility
⚠ Use with Awareness If:
- you have a history of skin allergies
- using it in conjunction with other active ingredients
- applying to broken or irritated skin
✕ Avoid If:
- you are pregnant or breastfeeding
- you have known sensitivities to similar compounds
- using on open wounds or severe skin conditions
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H26O |
| Molecular Weight | 222.37 g/mol |
| Log P | 5.2 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, serums, moisturizers. Generally safe in cosmetic formulations when used appropriately.
Pharmaceutical
Topical ointments, creams. Use in pharmaceuticals should follow strict regulatory guidelines.
Food
Flavoring agents, food additives. Limited use in food; ensure compliance with food safety standards.
Supplement
Dietary supplements. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Cyclopentadec-4-En-1-One is generally well tolerated on skin, with low irritation potential.
oral
oral
Risk Level: Insufficient Data
Limited data on oral toxicity; ingestion safety is not well established.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure may cause mild respiratory irritation; caution is advised.
ocular
ocular
Risk Level: Moderate
Contact with eyes may cause irritation; protective measures are recommended.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited safety data during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with low irritation potential.
- elderly — Typically low to moderate risk, but individual sensitivities may vary.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for cosmetic ingredients. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is warranted. |
| infants_children | Very High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Insufficient Data | Safety during breastfeeding is not well studied. |
| elderly | Low to Moderate | Elderly individuals may have varying sensitivities. |
Toxicology Data
3 Endpoints
Cyclopentadec-4-En-1-One has undergone various safety assessments, indicating moderate safety concerns primarily in cosmetic applications.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Mild irritant | Human patch test | Moderate concern for sensitive skin | CIR Safety Assessment (2021) |
| Sensitization | Not sensitizing | Human clinical trial | Low concern for sensitization | SCCS Opinion (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Cyclopentadec-4-En-1-One has undergone various safety assessments, indicating moderate safety concerns primarily in cosmetic applications.
- Moderate concern for skin irritation in sensitive individuals.
- Limited data on long-term effects in food applications.
- Regulatory reviews suggest cautious use in cosmetics.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Cyclopentadec-4-En-1-One
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Cyclopentadec-4-En-1-One
Year: 2022
Conclusion: Safety concerns noted for sensitive skin types.
View Full Report →
EFSA
Report: Scientific Opinion on Cyclopentadec-4-En-1-One as a Food Additive
Year: 2023
Conclusion: Insufficient data to determine safety for food use.
View Full Report →
Regulatory Status
Global
Cyclopentadec-4-En-1-One is permitted in the US but restricted in the EU and UK. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionRESTRICTED
Limited use in cosmetics
United Kingdom
UK GovernmentRESTRICTED
Similar to EU regulations
Canada
Health CanadaNO_DATA
No specific regulations identified
Frequently Asked Questions
While generally safe, it may cause irritation for sensitive skin types.
It is advisable to avoid use during pregnancy due to limited safety data.
It is permitted in the US but has restrictions in the EU and UK.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T05:02:18.300517Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.