9.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
flavor enhancer · fragrance component · aroma compound · potential antioxidant
3,7-Dimethylocta-2,6-Dienal
Molecular Weight
150.23 g/mol
Category
flavoring agent
Bottom Line: 3,7-Dimethylocta-2,6-Dienal is generally considered safe for use in cosmetics and food, though caution is advised based on individual sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below 0.1% in cosmetics
- Ingested as part of food flavoring within regulatory limits
- No known allergies to similar compounds
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- You are using other products containing similar flavoring agents
✕ Avoid If:
- You have a known allergy to this ingredient
- You experience irritation or adverse reactions
- You are using it in high concentrations without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Weight | 150.23 g/mol |
Common Use Cases
4 Categories
Cosmetic
Fragrances, lotions, shampoos. Generally safe in low concentrations; patch test recommended.
Food
Flavored beverages, confectionery, baked goods. Safe when used as a flavoring agent within limits.
Pharmaceutical
Medicated creams, oral solutions. Use under professional guidance; monitor for reactions.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 3,7-Dimethylocta-2,6-Dienal is generally well tolerated with minimal irritation.
oral
oral
Risk Level: Moderate
Ingestion may cause gastrointestinal discomfort; use caution with dosage.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact can cause significant irritation; avoid direct exposure to eyes.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure.
- pregnant — Limited safety data; use with caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal side effects.
- elderly — Generally well tolerated; monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated; monitor for any adverse reactions. |
| pregnant | Moderate | Limited data on safety during pregnancy; use with caution. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use cautiously. |
| elderly | Low | Generally well tolerated; monitor for any unusual reactions. |
Toxicology Data
3 Endpoints
3,7-Dimethylocta-2,6-Dienal has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | No irritation observed | EFSA Opinion (2018) |
| Sensitization | not sensitizing | Human clinical study | No sensitization reactions | FDA Regulatory Review (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
3,7-Dimethylocta-2,6-Dienal has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity observed in studies.
- Generally recognized as safe in regulated amounts.
- No significant adverse effects reported in standard use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Flavoring Agents
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2018
Conclusion: Considered safe for use in food flavoring.
View Full Report →
FDA
Report: Food Additive Status
Year: 2020
Conclusion: Permitted as a flavoring agent in food products.
View Full Report →
Regulatory Status
Global
3,7-Dimethylocta-2,6-Dienal is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Yes, it is permitted as a flavoring agent in food, but moderation is advised.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:24:46.231240Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.