9.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
Cosmetic Ingredient
Ambrocinate
Also known as: Methyl 2,6,10-trimethylundecanoic acid
Trade Names: Ambrocinate
Odor: Woody, ambery, musky
Category
general
Bottom Line: Generally regarded as safe when used appropriately, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to intact skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to the ingredient
- you experience irritation or adverse reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|
Common Use Cases
6 Categories
Cosmetic
Facial creams, sunscreens, moisturizers. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Generally recognized as safe in food applications.
Pharmaceutical
Topical ointments, oral medications. Use under medical supervision; potential for interactions.
Household
Cleaning agents, air fresheners. Follow usage instructions; ensure good ventilation.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use.
Veterinary
Pet shampoos, animal supplements. Use products specifically formulated for animals.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, with minimal irritation reported.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including gastrointestinal discomfort.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low, but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact can lead to significant irritation and potential damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity may lead to increased risk of adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in children may lead to adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may exist. |
Toxicology Data
3 Endpoints
Evidence suggests moderate safety for various applications, though individual reactions may vary.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2020) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | EFSA Opinion (2021) |
| Sensitization | not sensitizing | Human clinical study | No sensitization reactions reported | CIR Safety Assessment (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Evidence suggests moderate safety for various applications, though individual reactions may vary.
- Generally safe in recommended uses.
- Potential for skin irritation in sensitive individuals.
- Regulatory assessments support its use in cosmetics and food.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ingredient
Year: 2020
Conclusion: Safe for use in cosmetics at specified concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on Food Additives
Year: 2021
Conclusion: Considered safe for use in food applications.
View Full Report →
FDA
Report: Food and Cosmetic Ingredient Safety
Year: 2022
Conclusion: Generally recognized as safe for specified uses.
View Full Report →
Regulatory Status
Global
Overall, the ingredient is permitted for use across major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, some individuals may experience irritation; patch testing is advised.
Consult a healthcare provider before use during pregnancy to ensure safety.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:32:03.531770Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.