6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · intermediate · stabilizer
2-Sec-Butylcyclohexanone
Molecular Formula
C10H18O
Molecular Weight
154.25 g/mol
Category
chemical compound
Bottom Line: 2-Sec-Butylcyclohexanone is generally considered safe in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in well-formulated cosmetic products
- Concentration is within recommended limits
- Not used on broken skin
- Properly stored and handled
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in high concentrations
- Mixing with other potent chemicals
- Pregnant or nursing
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on open wounds or irritated skin
- Ingesting or using in food products
- Using in poorly ventilated areas
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H18O |
| Molecular Weight | 154.25 g/mol |
| Boiling Point | 76.0°C |
| Solubility | Miscible at room temperature (in ethanol) |
| Log P | 2.8 |
Common Use Cases
4 Categories
Cosmetic
Fragrances, skin creams, hair products. Generally safe in cosmetics when used as directed.
Pharmaceutical
Topical medications, ointments. Use with caution in pharmaceutical applications.
Household
Cleaning agents, air fresheners. Ensure proper ventilation when using household products.
Supplement
None identified. Not typically used in dietary supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 2-Sec-Butylcyclohexanone is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 2-Sec-Butylcyclohexanone poses moderate risks and should be avoided.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration.
ocular
ocular
Risk Level: High
Eye contact with 2-Sec-Butylcyclohexanone can cause significant irritation and damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is warranted. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
Toxicology Data
3 Endpoints
2-Sec-Butylcyclohexanone has limited safety data, but is generally regarded as safe in cosmetics and household products.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 18600 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not a skin irritant | SCCS Opinion (2016) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | FDA Registration (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
2-Sec-Butylcyclohexanone has limited safety data, but is generally regarded as safe in cosmetics and household products.
- Limited data on long-term exposure effects.
- Generally safe in low concentrations.
- Potential irritant for sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 2-Sec-Butylcyclohexanone
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on 2-Sec-Butylcyclohexanone
Year: 2016
Conclusion: Considered safe in cosmetic use under certain conditions.
View Full Report →
FDA
Report: Substance Registration
Year: 2020
Conclusion: No specific restrictions noted for cosmetic use.
View Full Report →
Regulatory Status
Global
2-Sec-Butylcyclohexanone is permitted in major jurisdictions with no specific restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should use caution.
Consult with a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:15:49.541473Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.