6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · flavoring agent · intermediate in organic synthesis · potential antioxidant
2-Methyl-3-Phenylprop-2-Enal
Molecular Formula
C10H10O
Molecular Weight
146.19 g/mol
Category
chemical compound
Bottom Line: 2-Methyl-3-Phenylprop-2-Enal is generally considered safe in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- used in low concentrations
- properly formulated in products
- not applied to broken skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to similar compounds
- you experience irritation or allergic reactions
- you are using products for children
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H10O |
| Molecular Weight | 146.19 g/mol |
| Boiling Point | 302.0°C |
| Solubility | miscible (in ethanol) |
| Log P | 2.2 |
Common Use Cases
3 Categories
Cosmetic
Fragrances, skin creams, lotions. Use in well-formulated products to minimize irritation risk.
Food
Flavoring agents, beverages. Generally safe in food applications at regulated levels.
Supplement
Dietary supplements. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to 2-Methyl-3-Phenylprop-2-Enal is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of 2-Methyl-3-Phenylprop-2-Enal may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with 2-Methyl-3-Phenylprop-2-Enal can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited data; potential risks to fetal development.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — May tolerate well but should be monitored.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity in infants and children; potential for adverse effects. |
| breastfeeding | Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low to Moderate | Elderly may have increased sensitivity; monitor for reactions. |
Toxicology Data
3 Endpoints
2-Methyl-3-Phenylprop-2-Enal has been evaluated for safety in cosmetics and food applications, showing low toxicity.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Rabbit - Draize test | Not a skin irritant | SCCS Opinion (2018) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2017) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
2-Methyl-3-Phenylprop-2-Enal has been evaluated for safety in cosmetics and food applications, showing low toxicity.
- Low acute toxicity in animal studies.
- Potential skin irritant for sensitive individuals.
- Regulatory assessments support safe use in cosmetics.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 2-Methyl-3-Phenylprop-2-Enal
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 0.5%.
View Full Report →
SCCS
Report: Opinion on 2-Methyl-3-Phenylprop-2-Enal
Year: 2018
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
EFSA
Report: Scientific Opinion on 2-Methyl-3-Phenylprop-2-Enal
Year: 2017
Conclusion: Acceptable daily intake established for food use.
View Full Report →
Regulatory Status
Global
2-Methyl-3-Phenylprop-2-Enal is permitted in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should use caution.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Possible side effects include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:10:55.666681Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.