10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
Fragrance ingredient · Odor masking agent · Sensory enhancer · Stabilizer
2',2',8',8'-Tetramethylspiro[1,3-Dioxolane-2,10'-Octahydro-1h-2,4a-Methanonapthalene]
Molecular Formula
C17H28O2
Molecular Weight
264.4 g/mol
Category
Fragrance
Bottom Line: Generally regarded as safe when used in low concentrations, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in cosmetic formulations at low concentrations
- applied to intact skin without irritation
- used in well-ventilated areas
- not ingested or used in food products
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in products for children
- exposed to high concentrations in industrial settings
- you are pregnant or nursing
✕ Avoid If:
- you have a known allergy to similar fragrance compounds
- using in food products without regulatory approval
- applying to broken or irritated skin
- using in enclosed spaces without ventilation
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C17H28O2 |
| Molecular Weight | 264.4 g/mol |
| Log P | 4.4 |
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, shampoos. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents. Not approved for food use in many jurisdictions.
Pharmaceutical
Topical creams. Ensure compliance with regulatory standards.
Household
Air fresheners, cleaning products. Use in well-ventilated areas to avoid inhalation risks.
Supplement
Aromatic oils. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on exposure levels.
ocular
ocular
Risk Level: High
Eye contact may cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity may lead to adverse effects.
- pregnant — Limited data necessitates caution.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally low to moderate risk, but monitor closely.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | Very High | Higher sensitivity in children may lead to adverse effects. |
| breastfeeding | Insufficient Data | Insufficient data on safety during breastfeeding. |
| elderly | Low to Moderate | Elderly individuals may have varying sensitivities. |
Toxicology Data
3 Endpoints
Safety assessments indicate low toxicity for 2',2',8',8'-Tetramethylspiro[1,3-Dioxolane-2,10'-Octahydro-1h-2,4a-Methanonapthalene].
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data for oral toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | non-irritating | Human patch test | Low irritation potential | SCCS Opinion (2018) |
| Sensitization | non-sensitizing | Human sensitization study | Low sensitization potential | CIR Safety Assessment (2015) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Safety assessments indicate low toxicity for 2',2',8',8'-Tetramethylspiro[1,3-Dioxolane-2,10'-Octahydro-1h-2,4a-Methanonapthalene].
- Low acute toxicity observed in studies.
- No significant skin irritation reported.
- Regulatory reviews support safe use in cosmetics.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Considered safe for use in cosmetic products.
View Full Report →
FDA
Report: Regulatory Status of Fragrance Ingredients
Year: 2020
Conclusion: Generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
Regulatory status is generally favorable across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally safe for skin use in low concentrations, though some may experience irritation.
Not approved for food use in many jurisdictions; consult local regulations.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:44:56.520386Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.