6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · intermediate · fragrance component · stabilizer
Isobutenyl Methyltetrahydropyran
Molecular Formula
C10H18O
Molecular Weight
154.25 g/mol
Category
chemical compound
Bottom Line: Isobutenyl Methyltetrahydropyran is generally considered safe for use in cosmetics and household products, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below recommended limits
- Formulated in products for external use only
- Not used by individuals with known sensitivities
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using multiple products containing similar compounds
- Pregnant or breastfeeding
✕ Avoid If:
- You experience irritation or allergic reactions
- Using on broken or damaged skin
- You are using it in high concentrations
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C10H18O |
| Molecular Weight | 154.25 g/mol |
| Boiling Point | 86.0°C |
| Solubility | soluble (in ethanol) |
| Log P | 2.9 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair styling products. Generally safe in cosmetic formulations when used as directed.
Pharmaceutical
Topical ointments, transdermal patches. Use in pharmaceuticals should follow strict regulatory guidelines.
Household
Cleaning agents, air fresheners. Ensure proper ventilation when using household products containing this ingredient.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Isobutenyl Methyltetrahydropyran is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of Isobutenyl Methyltetrahydropyran may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: High
Eye contact with Isobutenyl Methyltetrahydropyran can cause irritation and is considered high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposure may lead to adverse effects.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal risk.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no known severe reactions. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposure. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is advised. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
Toxicology Data
3 Endpoints
Isobutenyl Methyltetrahydropyran has limited safety data, but current assessments suggest it is safe for use in cosmetics and household products.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | CIR Safety Assessment (2021) |
| Sensitization | Not sensitizing | Human clinical study | No sensitization observed | SCCS Opinion (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Isobutenyl Methyltetrahydropyran has limited safety data, but current assessments suggest it is safe for use in cosmetics and household products.
- Limited data on long-term exposure effects.
- Generally safe in recommended concentrations.
- Potential for irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Isobutenyl Methyltetrahydropyran
Year: 2021
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Isobutenyl Methyltetrahydropyran
Year: 2022
Conclusion: Considered safe for cosmetic use with restrictions on concentration.
View Full Report →
FDA
Report: Regulatory Status of Isobutenyl Methyltetrahydropyran
Year: 2023
Conclusion: No specific restrictions; generally recognized as safe in cosmetics.
View Full Report →
Regulatory Status
Global
Isobutenyl Methyltetrahydropyran is generally permitted in major jurisdictions with some restrictions in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED WITH RESTRICTIONS
Max 5% in cosmetics
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should use caution and perform a patch test.
Consult with a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T06:21:29.267196Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.