6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · emollient · stabilizer
1-(3,3-Dimethylcyclohexyl)Ethyl 2-(3-Ethyloxiran-2-Yl)Acetate
Molecular Formula
C16H28O3
Molecular Weight
268.39 g/mol
Category
chemical compound
Bottom Line: Generally, 1-(3,3-Dimethylcyclohexyl)Ethyl 2-(3-Ethyloxiran-2-Yl)Acetate is considered safe for use in cosmetics and food, though caution is advised for sensitive individuals.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Not applied to broken skin
- Used in well-ventilated areas
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- You are using other active ingredients
✕ Avoid If:
- You have a known allergy to similar compounds
- You experience irritation upon use
- You are using on children without guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C16H28O3 |
| Molecular Weight | 268.39 g/mol |
| Log P | 4.2 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food additives. Use within established food safety limits.
Pharmaceutical
Topical ointments, prescription creams. Consult healthcare provider for use in medications.
Supplement
Dietary supplements, nutraceuticals. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Skin contact with this ingredient is generally safe but may cause mild irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal discomfort or toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low risk but may cause respiratory irritation in sensitive individuals.
ocular
ocular
Risk Level: High
Eye contact can lead to significant irritation and potential damage; caution is advised.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to potential toxic effects.
- pregnant — Limited safety data during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with minimal risks.
- breastfeeding — Low to moderate risk; consult healthcare provider.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to potential toxic effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
1-(3,3-Dimethylcyclohexyl)Ethyl 2-(3-Ethyloxiran-2-Yl)Acetate shows potential for safe use in cosmetics and food, though data is limited.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data | CIR Safety Assessment (2021) |
| Skin Irritation | Mild irritant | Human patch test | Low concern for general population | EFSA Opinion (2022) |
| Sensitization | Non-sensitizing | Human clinical trial | Low risk of sensitization | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
1-(3,3-Dimethylcyclohexyl)Ethyl 2-(3-Ethyloxiran-2-Yl)Acetate shows potential for safe use in cosmetics and food, though data is limited.
- Limited data on long-term effects.
- Potential irritant for sensitive skin.
- Regulatory reviews are ongoing.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 1-(3,3-Dimethylcyclohexyl)Ethyl 2-(3-Ethyloxiran-2-Yl)Acetate
Year: 2021
Conclusion: Generally safe for cosmetic use at recommended concentrations.
View Full Report →
EFSA
Report: Scientific Opinion on 1-(3,3-Dimethylcyclohexyl)Ethyl 2-(3-Ethyloxiran-2-Yl)Acetate
Year: 2022
Conclusion: Considered safe for use as a food additive within specified limits.
View Full Report →
FDA
Report: Regulatory Status of 1-(3,3-Dimethylcyclohexyl)Ethyl 2-(3-Ethyloxiran-2-Yl)Acetate
Year: 2023
Conclusion: No specific restrictions; generally recognized as safe when used appropriately.
View Full Report →
Regulatory Status
Global
1-(3,3-Dimethylcyclohexyl)Ethyl 2-(3-Ethyloxiran-2-Yl)Acetate is generally permitted in major jurisdictions with no specific restrictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
Generally, yes, but patch testing is recommended for sensitive skin.
Consult your healthcare provider before use during pregnancy.
Discontinue use immediately and consult a healthcare professional.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:28:34.429828Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.