66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · flavoring agent · aromatic compound
(2E)-2-(PHENYLMETHYLIDENE)OCTANAL
Category
fragrance compound
Bottom Line: Generally regarded as safe when used in cosmetics and food, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- Used in low concentrations in cosmetic formulations
- Not applied to broken skin
- Used in food products within regulatory limits
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- You are pregnant or nursing
- You are using multiple products containing fragrances
✕ Avoid If:
- You have a known allergy to fragrance compounds
- You experience irritation or adverse reactions
- You are using on children without prior testing
Chemical Properties
| Property | Value |
|---|
Common Use Cases
3 Categories
Cosmetic
Fragranced lotions, perfumes, shampoos. Use in moderation and perform patch tests to avoid reactions.
Food
Flavoring agents, beverages, confectionery. Generally safe in food applications within regulatory limits.
Supplement
Flavored supplements, nutritional bars. Consult a healthcare provider if unsure about use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to (2E)-2-(phenylmethylidene)octanal is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of (2E)-2-(phenylmethylidene)octanal may pose moderate risks due to limited data on toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, but data is limited.
ocular
ocular
Risk Level: High
Eye contact with (2E)-2-(phenylmethylidene)octanal may cause irritation, indicating high risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of adverse reactions due to developing systems.
- pregnant — Limited safety data; potential risks to fetal development.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- breastfeeding — Generally low risk, but caution is advised.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated by adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in children; potential for adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Research indicates that (2E)-2-(phenylmethylidene)octanal is generally safe for use in cosmetics and food, though some may experience sensitivities.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | Not available | Insufficient data | CIR Safety Assessment (2012) |
| Skin Irritation | Non-irritating | Human patch test | Low irritation potential | SCCS Opinion (2015) |
| Sensitization | Potential sensitizer | Human sensitization study | Moderate concern for sensitive individuals | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates that (2E)-2-(phenylmethylidene)octanal is generally safe for use in cosmetics and food, though some may experience sensitivities.
- Widely used in cosmetic and food products.
- Regulatory bodies have assessed its safety.
- Potential for allergic reactions in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2012
Conclusion: Safe for use in cosmetics at concentrations up to 1%.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2015
Conclusion: Considered safe for use in cosmetics with appropriate labeling.
View Full Report →
EFSA
Report: Scientific Opinion on Flavoring
Year: 2018
Conclusion: Safe for use in food flavoring applications.
View Full Report →
Regulatory Status
Global
Generally permitted in cosmetics and food across major jurisdictions with labeling requirements. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
Must be labeled as a fragrance
UK
UK GovernmentPERMITTED
Must comply with EU regulations post-Brexit
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
It may cause irritation in sensitive individuals; patch testing is recommended.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a healthcare professional if severe.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-19T17:25:22.413219Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.