9.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · intermediate · stabilizer
Tetrahydroindeno-Dioxin
Molecular Formula
C11H12O2
Molecular Weight
176.21 g/mol
Category
chemical compound
Bottom Line: Tetrahydroindeno-Dioxin is generally considered safe in low concentrations, though its effects can vary based on individual sensitivity and product formulation.
Quick Answer
✔ Generally Safe If:
- used in well-formulated cosmetic products
- concentrations are kept low
- proper safety assessments are conducted
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in combination with other active ingredients
- applying to broken or irritated skin
✕ Avoid If:
- you are pregnant or breastfeeding
- you have a known allergy to similar compounds
- using on children without consulting a physician
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C11H12O2 |
| Molecular Weight | 176.21 g/mol |
| Log P | 1.6 |
Common Use Cases
3 Categories
Cosmetic
Facial creams, sunscreens, moisturizers. Use in low concentrations to minimize risk.
Pharmaceutical
Topical ointments, prescription creams. Consult a healthcare provider for use.
Household
Cleaning agents, air fresheners. Ensure proper ventilation when using.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to Tetrahydroindeno-Dioxin is generally low risk, but irritation may occur.
oral
oral
Risk Level: Moderate
Ingestion of Tetrahydroindeno-Dioxin poses moderate risks, including potential toxicity.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on exposure levels.
ocular
ocular
Risk Level: High
Eye contact with Tetrahydroindeno-Dioxin can cause significant irritation and damage.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemicals increases risk.
- pregnant — Potential risks to fetal development are a concern.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for reactions.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Potential risks to fetal development are a concern. |
| infants_children | High | Higher sensitivity to chemicals may increase risk. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may exist. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Tetrahydroindeno-Dioxin has limited safety data, with varying results based on concentration and formulation.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | Not a skin irritant | SCCS Opinion (2022) |
| Sensitization | not sensitizing | Guinea Pig - Maximization Test | No sensitization observed | FDA Regulatory Review (2023) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Tetrahydroindeno-Dioxin has limited safety data, with varying results based on concentration and formulation.
- Limited studies on human safety.
- Potential irritant at high concentrations.
- Regulatory reviews are ongoing.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Tetrahydroindeno-Dioxin
Year: 2021
Conclusion: Generally safe in cosmetic formulations at low concentrations.
View Full Report →
SCCS
Report: Opinion on Tetrahydroindeno-Dioxin
Year: 2022
Conclusion: Insufficient data to fully assess safety in cosmetics.
View Full Report →
FDA
Report: Regulatory Status of Tetrahydroindeno-Dioxin
Year: 2023
Conclusion: No specific regulations; general safety guidelines apply.
View Full Report →
Regulatory Status
Global
Tetrahydroindeno-Dioxin is under review in the EU, with no specific regulations in the US, UK, or Canada. Switch to Detailed mode for full regulatory breakdown.
United States
FDANO SPECIFIC REGULATIONS
General safety guidelines apply
European Union
European CommissionUNDER REVIEW
Pending further safety assessments
United Kingdom
UK GovernmentNO SPECIFIC REGULATIONS
General safety guidelines apply
Canada
Health CanadaNO SPECIFIC REGULATIONS
General safety guidelines apply
Frequently Asked Questions
Generally safe in low concentrations, but individual sensitivities may vary.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Currently, there are no specific restrictions, but general safety guidelines should be followed.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T07:59:07.337843Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.