6.0
ISS Score
B — Acceptable — low-moderate concern
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
preservative · antioxidant · emulsifier
Iso E Super
Also known as: Octahydro-tetramethyl-naphthalenyl-ethanone, Isocyclemone E, Amberonne
Trade Names: Vertofix Coeur · Amber Xtreme · Timbersilk
Odor: Woody, ambery, cedarwood, slightly floral
Molecular Formula
C13H18O
Molecular Weight
190.28 g/mol
Category
preservation
Bottom Line: Generally considered safe for use in cosmetics and food, though individual sensitivities may vary.
Quick Answer
✔ Generally Safe If:
- used in recommended concentrations
- not combined with known irritants
- applied to intact skin
⚠ Use with Awareness If:
- you have sensitive skin
- you are pregnant or nursing
- you are using other active ingredients
✕ Avoid If:
- you have a known allergy to the ingredient
- you experience irritation or adverse reactions
- you are using on broken skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C13H18O |
| Molecular Weight | 190.28 g/mol |
| Log P | 3.3 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, shampoos, body lotions. Generally safe for topical use; patch test recommended.
Food
Flavoring agents, food preservatives. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical ointments, oral medications. Use as directed; consult a physician for concerns.
Supplement
Dietary supplements, herbal extracts. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, with minimal irritation reported.
oral
oral
Risk Level: Moderate
Oral ingestion may pose moderate risks, particularly at high doses.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low, but prolonged exposure may increase concerns.
ocular
ocular
Risk Level: Very Low
Ocular exposure is generally very low risk, with minor irritation possible.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher susceptibility to adverse effects due to developing systems.
- pregnant — Potential for increased sensitivity and effects on fetal development.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with minimal adverse effects.
- breastfeeding — Generally safe with proper guidance from healthcare providers.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Adults typically have a higher tolerance for exposure levels. |
| pregnant | Moderate | Pregnant individuals may have heightened sensitivity to certain substances. |
| infants_children | High | Infants and children are more vulnerable to adverse effects. |
| breastfeeding | Low to Moderate | Substances may transfer through breast milk; caution is advised. |
Toxicology Data
3 Endpoints
Evidence suggests moderate safety for cosmetic and food applications, though individual reactions may vary.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | non-irritating | Rabbit - Dermal application | No significant irritation observed | EFSA Opinion (2020) |
| Sensitization | not sensitizing | Guinea Pig - Maximization test | No sensitization potential | CIR Safety Assessment (2021) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Evidence suggests moderate safety for cosmetic and food applications, though individual reactions may vary.
- Generally safe in recommended doses.
- Potential for allergic reactions in sensitive individuals.
- Regulatory assessments support its use.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Ingredient
Year: 2021
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
EFSA
Report: Scientific Opinion on Food Additive
Year: 2020
Conclusion: Considered safe for use in food applications.
View Full Report →
FDA
Report: Food and Drug Administration Regulations
Year: 2022
Conclusion: Permitted for use in food and cosmetics.
View Full Report →
Regulatory Status
Global
Overall, the ingredient is permitted for use in major jurisdictions with no significant restrictions. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
None
EU
European CommissionPERMITTED
None
UK
UK GovernmentPERMITTED
None
CA
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should patch test before use.
Consult a healthcare provider before using any products during pregnancy.
Discontinue use immediately and consult a healthcare professional if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:10:42.571437Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.