9.0
ISS Score
A — Good — low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance · flavoring agent · solvent · stabilizer
6,10-Dimethyl-3-Propan-2-Ylidenespiro[4.5]Dec-9-En-8-One
Molecular Formula
C15H22O
Molecular Weight
218.33 g/mol
Category
chemical compound
Bottom Line: Generally, 6,10-Dimethyl-3-Propan-2-Ylidenespiro[4.5]Dec-9-En-8-One is considered safe in regulated uses, though caution is advised in sensitive populations.
Quick Answer
✔ Generally Safe If:
- Used in concentrations below regulatory limits
- Formulated in products with appropriate safety testing
- Not applied to broken skin or mucous membranes
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in conjunction with other active ingredients
- Pregnant or nursing women should consult a healthcare provider
✕ Avoid If:
- You have a known allergy to similar compounds
- Using on open wounds or irritated skin
- Using in high concentrations without proper guidance
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C15H22O |
| Molecular Weight | 218.33 g/mol |
| Log P | 3.2 |
Common Use Cases
4 Categories
Cosmetic
Facial creams, sunscreens, hair products. Generally safe in cosmetic formulations when used as directed.
Food
Flavoring agents, food additives. Use in food is regulated; ensure compliance with local guidelines.
Pharmaceutical
Topical medications, prescription creams. Safety in pharmaceuticals is assessed during clinical trials.
Supplement
Dietary supplements, herbal products. Consult a healthcare provider before use in supplements.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to this substance is generally low risk for most individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, particularly in high doses or sensitive individuals.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration and exposure duration.
ocular
ocular
Risk Level: High
Eye contact may result in significant irritation or damage, warranting caution.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity may lead to increased risk of adverse effects.
- pregnant — Limited data necessitates caution during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated with proper use.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in infants and children may increase risk of adverse effects. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but age-related sensitivities may exist. |
Toxicology Data
3 Endpoints
6,10-Dimethyl-3-Propan-2-Ylidenespiro[4.5]Dec-9-En-8-One has been evaluated for safety in various applications, with mixed findings.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2021) |
| Skin Irritation | Non-irritating | Rabbit - Dermal application | No significant irritation observed | SCCS Opinion (2022) |
| Sensitization | Not sensitizing | Guinea Pig - Maximization test | No sensitization observed | EFSA Opinion (2023) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
6,10-Dimethyl-3-Propan-2-Ylidenespiro[4.5]Dec-9-En-8-One has been evaluated for safety in various applications, with mixed findings.
- Safety assessments vary by jurisdiction and application
- Limited data available on long-term effects
- Regulatory bodies continue to monitor its use
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 6,10-Dimethyl-3-Propan-2-Ylidenespiro[4.5]Dec-9-En-8-One
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on 6,10-Dimethyl-3-Propan-2-Ylidenespiro[4.5]Dec-9-En-8-One
Year: 2022
Conclusion: Insufficient data to fully assess safety in cosmetic use.
View Full Report →
EFSA
Report: Evaluation of 6,10-Dimethyl-3-Propan-2-Ylidenespiro[4.5]Dec-9-En-8-One as a food additive
Year: 2023
Conclusion: Considered safe for use in food at specified limits.
View Full Report →
Regulatory Status
Global
Regulatory status varies; permitted in the US and UK, restricted in the EU. Switch to Detailed mode for full regulatory breakdown.
US
FDAPERMITTED
Must comply with safety regulations
EU
European CommissionRESTRICTED
Limited use in cosmetics
UK
UK GovernmentPERMITTED
Must comply with safety regulations
CA
Health CanadaNO DATA
Frequently Asked Questions
Generally considered safe in cosmetics at regulated concentrations, though individual reactions may vary.
Caution is advised; perform a patch test or consult a dermatologist before use.
It is regulated as a food additive; ensure compliance with local food safety guidelines.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:47:15.651120Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.