10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
solvent · fragrance ingredient · stabilizer · emollient
[1-Methyl-2-[(1,2,2-Trimethyl-3-Bicyclo[3.1.0]Hexanyl)Methyl]Cyclopropyl]Methanol
Category
chemical compound
Bottom Line: Generally, 1-Methyl-2-[(1,2,2-Trimethyl-3-Bicyclo[3.1.0]Hexanyl)Methyl]Cyclopropyl]Methanol is considered safe in cosmetics and supplements, though individual reactions may vary.
Quick Answer
✔ Generally Safe If:
- Used in recommended concentrations
- Formulated for topical application
- No known allergies to similar compounds
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using other active ingredients in products
- Pregnant or nursing
✕ Avoid If:
- You have a known allergy to this ingredient
- Using on broken or irritated skin
- Undergoing dermatological treatments
Chemical Properties
| Property | Value |
|---|
Common Use Cases
3 Categories
Cosmetic
Facial creams, sunscreens, hair conditioners. Generally safe for topical use; patch test recommended.
Pharmaceutical
Topical analgesics, anti-inflammatory creams. Use as directed; consult a healthcare provider if unsure.
Supplement
Dietary supplements, herbal extracts. Consult a healthcare professional before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure is generally low risk, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion may pose moderate risks, including potential gastrointestinal irritation.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation risks are typically low to moderate, depending on concentration and exposure duration.
ocular
ocular
Risk Level: High
Eye contact may cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity and risk of adverse effects.
- pregnant — Limited data; caution advised.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with proper use.
- elderly — Low to moderate risk; monitor closely.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity in children; potential for adverse effects. |
| breastfeeding | Insufficient Data | Insufficient data on safety during breastfeeding. |
| elderly | Low to Moderate | Elderly may have increased sensitivity; monitor for adverse effects. |
Toxicology Data
3 Endpoints
1-Methyl-2-[(1,2,2-Trimethyl-3-Bicyclo[3.1.0]Hexanyl)Methyl]Cyclopropyl]Methanol shows potential for safe use in cosmetics and supplements, though data is limited.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | Not established | — | Insufficient data | — |
| Skin Irritation | Mild irritant | Human patch test | Low concern for irritation | CIR Safety Assessment (2021) |
| Sensitization | Non-sensitizing | Human clinical trial | Low concern for sensitization | SCCS Opinion (2022) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
1-Methyl-2-[(1,2,2-Trimethyl-3-Bicyclo[3.1.0]Hexanyl)Methyl]Cyclopropyl]Methanol shows potential for safe use in cosmetics and supplements, though data is limited.
- Limited safety data available
- Potential for skin irritation
- Regulatory assessments ongoing
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of 1-Methyl-2-[(1,2,2-Trimethyl-3-Bicyclo[3.1.0]Hexanyl)Methyl]Cyclopropyl]Methanol
Year: 2021
Conclusion: Generally safe for use in cosmetics at recommended concentrations.
View Full Report →
SCCS
Report: Opinion on 1-Methyl-2-[(1,2,2-Trimethyl-3-Bicyclo[3.1.0]Hexanyl)Methyl]Cyclopropyl]Methanol
Year: 2022
Conclusion: Insufficient data to fully assess safety; further studies recommended.
View Full Report →
FDA
Report: Regulatory Status of 1-Methyl-2-[(1,2,2-Trimethyl-3-Bicyclo[3.1.0]Hexanyl)Methyl]Cyclopropyl]Methanol
Year: 2023
Conclusion: No specific regulations; generally recognized as safe in cosmetics.
View Full Report →
Regulatory Status
Global
Regulatory status varies; generally permitted in the US and UK, under review in the EU. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionUNDER REVIEW
Pending further studies
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaNO DATA
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test first.
Consult a healthcare provider before using products with this ingredient during pregnancy.
Discontinue use immediately and consult a dermatologist if irritation occurs.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T02:35:50.936325Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.