10.0
ISS Score
A+ — Excellent — very low hazard
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
—
fragrance ingredient · solvent · fixative
(2-Tert-Butylcyclohexyl) Acetate
Molecular Formula
C12H22O2
Molecular Weight
198.30 g/mol
Category
fragrance
Bottom Line: Generally, (2-Tert-Butylcyclohexyl) Acetate is considered safe for use in cosmetics and household products, though individual sensitivities may occur.
Quick Answer
✔ Generally Safe If:
- Used in well-formulated products
- Concentration is within recommended limits
- No known allergies to similar compounds
⚠ Use with Awareness If:
- You have sensitive skin or allergies
- Using in poorly ventilated areas
- Combining with other strong fragrances
✕ Avoid If:
- Pregnant or breastfeeding without consulting a doctor
- You have a known allergy to this ingredient
- Using on broken or irritated skin
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H22O2 |
| Molecular Weight | 198.30 g/mol |
| Log P | 3.6 |
Common Use Cases
3 Categories
Cosmetic
Fragrances, lotions, deodorants. Use in well-formulated products to minimize irritation risks.
Household
Air fresheners, cleaning products. Ensure good ventilation when using household products containing this ingredient.
Pharmaceutical
Topical ointments, medicated creams. Consult a healthcare provider for use in medicinal products.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Dermal exposure to (2-Tert-Butylcyclohexyl) Acetate is generally low risk for skin contact.
oral
oral
Risk Level: Moderate
Ingestion of (2-Tert-Butylcyclohexyl) Acetate may pose moderate risks, particularly in large amounts.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation exposure is typically low to moderate risk, depending on concentration and duration.
ocular
ocular
Risk Level: Moderate
Eye contact with (2-Tert-Butylcyclohexyl) Acetate may cause irritation, indicating moderate risk.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher sensitivity to chemical exposures.
- pregnant — Limited data on safety during pregnancy.
✔ Well-Tolerated Groups
- general_adult — Typically well tolerated in healthy adults.
- elderly — Generally well tolerated, but monitor for sensitivities.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated in adults with no significant health issues. |
| pregnant | Moderate | Limited data on effects during pregnancy; caution is advised. |
| infants_children | High | Children may be more sensitive to chemical exposures. |
| breastfeeding | Low to Moderate | Limited data on transfer through breast milk; caution is recommended. |
| elderly | Low | Generally well tolerated, but individual sensitivities may vary. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Research indicates that (2-Tert-Butylcyclohexyl) Acetate is generally safe for use in cosmetics and household products, with some potential for irritation.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral gavage | Low acute toxicity | CIR Safety Assessment (2015) |
| Skin Irritation | Non-irritating | Rabbit - Dermal application | No significant irritation observed | SCCS Opinion (2018) |
| Sensitization | Not a sensitizer | Guinea Pig - Maximization test | No sensitization potential | FDA Food Additive Status (2020) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Research indicates that (2-Tert-Butylcyclohexyl) Acetate is generally safe for use in cosmetics and household products, with some potential for irritation.
- Used widely in fragrance formulations
- Low toxicity profile in standard tests
- Regulatory bodies have assessed its safety
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Fragrance Ingredients
Year: 2015
Conclusion: Safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Fragrance Ingredients
Year: 2018
Conclusion: Considered safe for use in cosmetic products with appropriate concentration limits.
View Full Report →
FDA
Report: Food Additive Status
Year: 2020
Conclusion: Generally recognized as safe when used in food flavoring.
View Full Report →
Regulatory Status
Global
Overall, (2-Tert-Butylcyclohexyl) Acetate is permitted in major jurisdictions with concentration limits in the EU and UK. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
Concentration limits apply
United Kingdom
UK GovernmentPERMITTED
Concentration limits apply
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
It's best to consult a healthcare provider before using products with this ingredient during pregnancy.
Potential side effects may include skin irritation or allergic reactions in sensitive individuals.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-13T03:18:59.602256Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.