66.0
ISS Score
Moderate — Score based on regulatory approval status in 4 jurisdiction(s), route-level risk assessment across multiple routes, and 3 toxicology endpoints from safety assessments.
↑ Higher = Safer
Environmental
(ESS)
(ESS)
—
Confidence
(CSS)
(CSS)
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Fragrance ingredient · Solvent · Emollient
Amyl Salicylate
Also known as: Salicylic acid amyl ester, Amyl 2-hydroxybenzoate
Molecular Formula
C12H16O3
Molecular Weight
208.25 g/mol
Category
Fragrance
Bottom Line: Amyl Salicylate is generally considered safe in cosmetics and fragrances, though some individuals may experience sensitivities.
Quick Answer
✔ Generally Safe If:
- used in low concentrations in cosmetic products
- not applied to broken skin
- used in well-ventilated areas
- not combined with known allergens
⚠ Use with Awareness If:
- you have sensitive skin or allergies
- using in products for children
- exposed to sunlight after application
- using in conjunction with other fragrances
✕ Avoid If:
- you are pregnant or breastfeeding
- you have a known allergy to salicylates
- you experience irritation or allergic reactions
- using in high concentrations
Chemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C12H16O3 |
| Molecular Weight | 208.25 g/mol |
| Boiling Point | 268.0°C |
| Solubility | 5 mg/L @ 20 °C (exp) |
| Log P | 5.2 |
Common Use Cases
5 Categories
Cosmetic
Fragrances, lotions, deodorants. Use in low concentrations to minimize irritation risk.
Food
Flavoring agents, confectionery. Generally recognized as safe when used appropriately.
Pharmaceutical
Topical analgesics. Monitor for allergic reactions in sensitive individuals.
Household
Air fresheners, cleaning products. Ensure good ventilation during use.
Supplement
Aromatic oils. Consult a healthcare provider before use.
Safety by Route of Exposure
dermal
dermal
Risk Level: Low
Amyl Salicylate is generally well tolerated on the skin, but may cause irritation in sensitive individuals.
oral
oral
Risk Level: Moderate
Ingestion of Amyl Salicylate can lead to gastrointestinal discomfort and should be avoided.
inhalation
inhalation
Risk Level: Low to Moderate
Inhalation may cause respiratory irritation; use in well-ventilated areas.
ocular
ocular
Risk Level: High
Contact with eyes can cause significant irritation and should be avoided.
Who Should Use or Avoid
⚠ Higher Risk Groups
- infants_children — Higher risk of irritation and adverse reactions.
- pregnant — Limited safety data; consult healthcare provider.
✔ Well-Tolerated Groups
- general_adult — Generally well tolerated with minimal risk.
- breastfeeding — Use with caution; consult healthcare provider.
Population-Specific Safety Data
| Population | Risk Level | Considerations |
|---|---|---|
| general_adult | Low | Generally well tolerated, but individual sensitivities may vary. |
| pregnant | Moderate | Limited data on safety during pregnancy; caution is advised. |
| infants_children | High | Higher sensitivity to chemicals; potential for adverse reactions. |
| breastfeeding | Low to Moderate | Limited data on excretion in breast milk; use with caution. |
| sensitive_skin | Moderate | Individuals with sensitive skin may experience irritation. |
Toxicology Data
3 Endpoints
Amyl Salicylate is a fragrance ingredient with a moderate safety profile, though some individuals may experience sensitivities.
| Endpoint | Value | Test Method | Interpretation | Source |
|---|---|---|---|---|
| LD50 Oral | 5000 mg/kg | Rat - Oral | Low acute toxicity | CIR Safety Assessment (2012) |
| Skin Irritation | non-irritating | Human patch test | No significant irritation observed | SCCS Opinion (2015) |
| Sensitization | not sensitizing | Human sensitization study | No sensitization reactions reported | EFSA Opinion (2018) |
Data Quality: All toxicology values are sourced from verified regulatory assessments (CIR, SCCS, ECHA REACH) following OECD test guidelines. Values are used to calculate the Ingredient Safety Score (ISS).
Scientific Evidence
Key Assessments
Amyl Salicylate is a fragrance ingredient with a moderate safety profile, though some individuals may experience sensitivities.
- Used widely in cosmetics and fragrances.
- Regulatory bodies have assessed its safety.
- Potential for skin irritation in sensitive individuals.
Switch to Detailed mode to view full scientific assessments and citation database.
CIR
Report: Safety Assessment of Amyl Salicylate
Year: 2012
Conclusion: Amyl Salicylate is safe for use in cosmetics at concentrations up to 5%.
View Full Report →
SCCS
Report: Opinion on Amyl Salicylate
Year: 2015
Conclusion: Considered safe for use in cosmetic products with proper labeling.
View Full Report →
EFSA
Report: Scientific Opinion on Flavouring
Year: 2018
Conclusion: Amyl Salicylate is safe for use as a flavoring agent in food.
View Full Report →
Regulatory Status
Global
Amyl Salicylate is permitted for use in cosmetics and food across major jurisdictions. Switch to Detailed mode for full regulatory breakdown.
United States
FDAPERMITTED
None
European Union
European CommissionPERMITTED
None
United Kingdom
UK GovernmentPERMITTED
None
Canada
Health CanadaPERMITTED
None
Frequently Asked Questions
While generally safe, individuals with sensitive skin should perform a patch test before use.
Yes, it is permitted as a flavoring agent in food, but should be used within recommended limits.
Discontinue use immediately and consult a healthcare professional if irritation persists.
Version History
Audit Trail
| Version | Date | ISS Score | What Changed |
|---|---|---|---|
| 1.0.0 - Initial enrichment | 2026-04-29T06:57:33.091266Z | — | Initial data enrichment via 3-phase structured outputs |
⚠ Important Notice: This information is for educational purposes only and does not constitute medical, professional, or regulatory advice. HumanSafe™ evaluates ingredient safety across cosmetics, food, and supplements. Scores are exposure-route and context-specific. Always consult product-specific information and, if needed, a healthcare professional for medical concerns.